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Titolo:
Loss of expression of human spectrin src homology domain binding protein 1is associated with 10p loss in human prostatic adenocarcinoma
Autore:
Macoska, JA; Xu, JL; Ziemnicka, D; Schwab, TS; Rubin, MA; Kotula, L;
Indirizzi:
New York State Inst Basic Res Dev Disabil, Mol Neurobiol Lab, Dept Pathol Neurobiol, Staten Isl, NY 10314 USA New York State Inst Basic Res Dev Disabil Staten Isl NY USA 10314 314 USA Univ Michigan, Sch Med, Dept Surg, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 , Dept Surg, Ann Arbor, MI 48109 USA Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 Dept Pathol, Ann Arbor, MI 48109 USA
Titolo Testata:
NEOPLASIA
fascicolo: 2, volume: 3, anno: 2001,
pagine: 99 - 104
SICI:
1522-8002(200103/04)3:2<99:LOEOHS>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPIDERMAL GROWTH-FACTOR; ALLELIC LOSS; PHOSPHOINOSITIDE 3-KINASE; TUMOR SUPPRESSION; C-ABL; CANCER; CHROMOSOME-10; CARCINOMA; CELLS; MACROPINOCYTOSIS;
Keywords:
spectrin; Src homology domain; tumorigenesis; tyrosine kinase; prostate cancer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Kotula, L New York State Inst Basic Res Dev Disabil, Mol Neurobiol Lab, Dept Pathol Neurobiol, 1050 Forest Hill Rd, Staten Isl, NY 10314 USA New YorkState Inst Basic Res Dev Disabil 1050 Forest Hill Rd Staten Isl NY USA 10314
Citazione:
J.A. Macoska et al., "Loss of expression of human spectrin src homology domain binding protein 1is associated with 10p loss in human prostatic adenocarcinoma", NEOPLASIA, 3(2), 2001, pp. 99-104

Abstract

The gene encoding human spectrin Src homology domain binding protein I, orHssh3bp1, which is a marker of macropinocytic vesicles and a potential regulator of macropinocytosis, co-localizes to a YAC containing chromosome 10psequences at loci D10S89 and D10S111 that are frequently deleted in prostate tumors. Expression of Hssh3bp1 was evaluated at the protein level in II paired normal and malignant prostate tumor samples using the monoclonal antibody 2G8 to Hssh3bp1. These experiments demonstrated that 4/6 tumors (67%)with 10p deletion failed to express Hssh3bp1 protein compared to 5/11 (46%) tumors with intact 10p. Thus, loss of Hssh3bp1 expression is concordant with allelic loss of adjacent 10p sequences in human prostate tumors, In addition, two prostate tumor cell lines contain an exon skipping mutation in the Hssh3bp1 gene that leads to the abnormal splicing of the mRNA and loss of a portion of Abl tyrosine kinase SH3 domain binding site in the protein. These data are consistent with a role for Hssh3bp1 as a candidate tumor suppressor gene inactivated during prostate tumorigenesis.

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Documento generato il 06/04/20 alle ore 04:40:29