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Titolo:
Glutamatergic-cholinergic synergistic interaction in the pontine reticularformation. Effects on catalepsy
Autore:
Elazar, Z; Berchanski, A;
Indirizzi:
Tel Aviv Univ, Sackler Sch Med, Dept Physiol & Pharmacol, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 rmacol, IL-69978 Tel Aviv, Israel
Titolo Testata:
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
fascicolo: 5, volume: 363, anno: 2001,
pagine: 569 - 576
SICI:
0028-1298(200105)363:5<569:GSIITP>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYL-D-ASPARTATE; NEUROLEPTIC-INDUCED CATALEPSY; HALOPERIDOL-INDUCED CATALEPSY; NMDA RECEPTORS; BRAIN-STEM; REM-SLEEP; ACETYLCHOLINE-RELEASE; NEOCORTICAL NEURONS; PARADOXICAL SLEEP; BASAL GANGLIA;
Keywords:
catalepsy; pontine reticular formation; carbachol; excitatory amino acids; interaction between carbachol and excitatory amino acids;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Elazar, Z Tel Aviv Univ, Sackler Sch Med, Dept Physiol & Pharmacol, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 -69978 Tel Aviv, Israel
Citazione:
Z. Elazar e A. Berchanski, "Glutamatergic-cholinergic synergistic interaction in the pontine reticularformation. Effects on catalepsy", N-S ARCH PH, 363(5), 2001, pp. 569-576

Abstract

Microinjections of small amounts of the cholinergic receptor agonists carbachol and nicotine into the pontine reticular formation (PRF) of rats were shown to induce catalepsy. Catalepsy was used in this work as an experimental model for studying the interactions between cholinergic mechanisms and excitatory amino acid mechanisms in the PRE The excitatory amino acid (EAA) receptor agonists glutamate, NMDA, kainate and AR;IPA were microinjected insubcataleptic doses before carbachol in the same location into the PRE Allthe EAA receptor agonists injected induced a significant potentiation of the cataleptogenic effect of carbachol. The NMDA receptor antagonist MK-801 and the non-NMDA receptor antagonist DNQX microinjected in picomol doses before the EAA receptor agonists attenuated their potentiating effect. These results support the suggestion that EAA neuronal mechanisms contribute synergistically with the cholinergic mechanisms to the PRF neuronal interactions involved in the generation of catalepsy. Similar synergistic interactionsmight be active in the generation of ether pontine behavioral manifestations like REM sleep.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 08:15:37