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Titolo:
Involvement of inhibitory NKRs in the survival of a subset of memory-phenotype CD8(+) T cells
Autore:
Ugolini, S; Arpin, C; Anfossi, N; Walzer, T; Cambiaggi, A; Forster, R; Lipp, M; Toes, REM; Melief, CJ; Marvel, J; Vivier, E;
Indirizzi:
CNRS Marseille Luminy, INSERM, Ctr Immuno, F-13288 Marseille 09, France CNRS Marseille Luminy Marseille France 09 , F-13288 Marseille 09, France INSERM, U503, CERVI, Lyon, France INSERM Lyon FranceINSERM, U503, CERVI, Lyon, France Univ Oxford, Sir William Dunn Sch Pathol, Oxford, England Univ Oxford Oxford England Sir William Dunn Sch Pathol, Oxford, England Max Delbruck Ctr Mol Med, Berlin, Germany Max Delbruck Ctr Mol Med Berlin Germany ck Ctr Mol Med, Berlin, Germany Leiden Univ, Ctr Med, Dept Immunohaematol & Bloodbank, Leiden, NetherlandsLeiden Univ Leiden Netherlands aematol & Bloodbank, Leiden, Netherlands
Titolo Testata:
NATURE IMMUNOLOGY
fascicolo: 5, volume: 2, anno: 2001,
pagine: 430 - 435
SICI:
1529-2908(200105)2:5<430:IOINIT>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLASS-I MOLECULES; TRANSGENIC MICE; LYMPHOKINE PRODUCTION; RECEPTORS; LYMPHOCYTES; EXPRESSION; ANTIGEN; CYTOTOXICITY; TOLERANCE; RESPONSES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Vivier, E CNRS Marseille Luminy, INSERM, Ctr Immuno, Case 906, F-13288 Marseille 09,France CNRS Marseille Luminy Case 906 Marseille France 09 le 09,France
Citazione:
S. Ugolini et al., "Involvement of inhibitory NKRs in the survival of a subset of memory-phenotype CD8(+) T cells", NAT IMMUNOL, 2(5), 2001, pp. 430-435

Abstract

Inhibitory natural killer receptors (NKRs) such as killer cell immunoglobulin-like receptors (KIRs) in humans and Ly49 molecules in mice are expressed on NK cells and recognize multiple major histocompatibility (MHC) class Iproteins. In humans and mice, a subset of CD8(+)T cells also expresses NKRs and harbors a memory phenotype. Using mice that are transgenic for KIR2DL3 and its cognate HLA-Cw3 ligand, we show that engagement of inhibitory NKRs selectively drives the in vivo accumulation of a subset of memory-phenotype CD8(+) T cells that express the beta chain of the interleukin 2 receptor. In vitro, recognition of MHC class I molecules by inhibitory NKRs on T cells down-regulated activation-induced cell death. These results unveil an MHC class I-dependent pathway that promotes the survival of a subset of memory-phenotype CD8(+)T cells and also reveal an unexpected biological function for inhibitory NKRs on T cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 22:17:59