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Titolo:
SAP controls T cell responses to virus and terminal differentiation of T(H)2 cells
Autore:
Wu, CB; Nguyen, KB; Pien, GC; Wang, NH; Gullo, C; Howie, D; Sosa, MR; Edwards, MJ; Borrow, P; Satoskar, AR; Sharpe, AH; Biron, CA; Terhorst, C;
Indirizzi:
Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Immunol, Boston,MA 02115 USA Harvard Univ Boston MA USA 02115 ed Ctr, Div Immunol, Boston,MA 02115 USA Brown Univ, Div Biol & Med, Dept Mol Microbiol & Immunol, Providence, RI 02912 USA Brown Univ Providence RI USA 02912 ol & Immunol, Providence, RI 02912 USA Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 munol & Infect Dis, Boston, MA 02115 USA Edward Jenner Inst Vaccine Res, Newbury RG20 7NN, Berks, England Edward Jenner Inst Vaccine Res Newbury Berks England RG20 7NN ks, England Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 pt Pathol, Boston, MA 02115 USA Harvard Univ, Sch Med, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 vard Univ, Sch Med, Boston, MA 02115 USA
Titolo Testata:
NATURE IMMUNOLOGY
fascicolo: 5, volume: 2, anno: 2001,
pagine: 410 - 414
SICI:
1529-2908(200105)2:5<410:SCTCRT>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
LINKED LYMPHOPROLIFERATIVE-DISEASE; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; PROMPTLY PRODUCE INTERLEUKIN-4; LEISHMANIA-MAJOR; VIRAL-INFECTION; NATURAL-KILLER; ENCODING GENE; CUTTING EDGE; BALB/C MICE; ACTIVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Terhorst, C Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Immunol, Boston,MA 02115 USA Harvard Univ Boston MA USA 02115 Immunol, Boston,MA 02115 USA
Citazione:
C.B. Wu et al., "SAP controls T cell responses to virus and terminal differentiation of T(H)2 cells", NAT IMMUNOL, 2(5), 2001, pp. 410-414

Abstract

SH2DIA, which encodes signaling lymphocyte activation molecule (SLAM)-associated protein (SAP), is altered in patients with X-linked lymphoproliferative disease (XLP), a primary immunodeficiency, SAP-deficient mice infected with lymphocytic choriomeningitis virus had greatly increased numbers of CD8(+) and CD4(+) interferon-gamma -producing spleen and liver cells comparedto wild-type mice. The immune responses of SAP-deficient mice to infectionwith Leishmania major together with in vitro studies showed that activatedSAP-deficient T cells had an impaired ability to differentiate into T helper 2 cells,The aberrant immune responses in SAP-deficient mice show that SAP controls several distinct key T cell signal transduction pathways, which explains in pare the complexity of the XLP phenotypes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 14:07:24