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Titolo:
A glia-derived acetylcholine-binding protein that modulates synaptic transmission
Autore:
Smit, AB; Syed, NI; Schaap, D; van Minnen, J; Klumperman, J; Kits, KS; Lodder, H; van der Schors, RC; van Elk, R; Sorgedrager, B; Brejc, K; Sixma, TK; Geraerts, WPM;
Indirizzi:
Free Univ Amsterdam, Fac Biol, Neurosci Res Inst, Dept Mol & Cellular Neurobiol, NL-1081 HV Amsterdam, Netherlands Free Univ Amsterdam Amsterdam Netherlands NL-1081 HV terdam, Netherlands Netherlands Canc Inst, Div Mol Carcinogenesis, NL-1066 CX Amsterdam, Netherlands Netherlands Canc Inst Amsterdam Netherlands NL-1066 CX rdam, Netherlands Univ Calgary, Dept Cell Biol & Anat, Calgary, AB T2N 4N1, Canada Univ Calgary Calgary AB Canada T2N 4N1 Anat, Calgary, AB T2N 4N1, Canada Univ Utrecht, Med Ctr, Dept Cell Biol, Inst Biomembranes, NL-3584 CX Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3584 CX 3584 CX Utrecht, Netherlands Ctr Biogenet, NL-3584 CX Utrecht, Netherlands Ctr Biogenet Utrecht Netherlands NL-3584 CX 3584 CX Utrecht, Netherlands Organon Teknika BV, Biosci Res Unit, Boxtel, Netherlands Organon Teknika BV Boxtel Netherlands sci Res Unit, Boxtel, Netherlands
Titolo Testata:
NATURE
fascicolo: 6835, volume: 411, anno: 2001,
pagine: 261 - 268
SICI:
0028-0836(20010517)411:6835<261:AGAPTM>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
IDENTIFIED LYMNAEA NEURONS; CULTURED HIPPOCAMPAL-NEURONS; FROG NEUROMUSCULAR-JUNCTION; PERISYNAPTIC SCHWANN-CELLS; ASTROCYTES IN-SITU; INTRACELLULAR CALCIUM; NICOTINIC RECEPTORS; SUBUNIT; SYNAPTOGENESIS; COMMUNICATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Smit, AB Free Univ Amsterdam, Fac Biol, Neurosci Res Inst, Dept Mol & Cellular Neurobiol, De Boelelaan 1087, NL-1081 HV Amsterdam, Netherlands Free Univ Amsterdam De Boelelaan 1087 Amsterdam Netherlands NL-1081 HV
Citazione:
A.B. Smit et al., "A glia-derived acetylcholine-binding protein that modulates synaptic transmission", NATURE, 411(6835), 2001, pp. 261-268

Abstract

There is accumulating evidence that glial cells actively modulate neuronalsynaptic transmission. We identified a glia-derived soluble acetylcholine-binding protein (AChBP), which is a naturally occurring analogue of the ligand-binding domains of the nicotinic acetylcholine receptors (nAChRs). Likethe nAChRs, it assembles into a homopentamer with ligand-binding characteristics that are typical for a nicotinic receptor; unlike the nAChRs, however, it lacks the domains to form a transmembrane ion channel. Presynaptic release of acetylcholine induces the secretion of AChBP through the glial secretory pathway. We describe a molecular and cellular mechanism by which glial cells release AChBP in the synaptic cleft, and propose a model for how they actively regulate cholinergic transmission between neurons in the central nervous system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 00:54:21