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Titolo:
Possible roles of JNK pathway in the regulation of hippocampal proenkephalin and immediate early gene expression induced by kainic acid
Autore:
Kim, YH; Choi, SS; Lee, JK; Won, JS; Choi, MR; Suh, HW;
Indirizzi:
Hallym Univ, Coll Med, Inst Nat Med, Dept Pharmacol, Chunchon 200702, South Korea Hallym Univ Chunchon South Korea 200702 ol, Chunchon 200702, South Korea
Titolo Testata:
MOLECULES AND CELLS
fascicolo: 2, volume: 11, anno: 2001,
pagine: 144 - 150
SICI:
1016-8478(20010430)11:2<144:PROJPI>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELEMENT-BINDING PROTEIN; RAT HIPPOCAMPUS; MESSENGER-RNA; C-FOS; INDUCED SEIZURES; GROWTH-FACTOR; GLIOMA-CELLS; PRODYNORPHIN; JUN; BRAIN;
Keywords:
c-fos; c-jun; CREB; hippocampus; JNK; kainic acid; proenkephalin; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Suh, HW Hallym Univ, Coll Med, Inst Nat Med, Dept Pharmacol, Chunchon 200702, South Korea Hallym Univ Chunchon South Korea 200702 chon 200702, South Korea
Citazione:
Y.H. Kim et al., "Possible roles of JNK pathway in the regulation of hippocampal proenkephalin and immediate early gene expression induced by kainic acid", MOL CELLS, 11(2), 2001, pp. 144-150

Abstract

Mitogen-activated protein kinases (MAPKs) may play crucial roles in the kainic acid (KA)-evoked excitotoxic effect and the regulation of transcription factors (e,g, c-Fos and c-Jun) in hippocampus, but their exact role in the regulation of KA-induced opioid peptides expression has not been well characterized in vivo. Therefore, we examined possible involvement of the phosphorylated form of JNK, as well as CREB, in the regulation of KA-induced proenkephalin and immediate early genes (IEGs) expression in the rat hippocampus, KA increased proenkephalin mRNA expression in rat hippocampus, which was decreased by pre-administration with cycloheximide (CHX, a protein synthesis inhibitor). KA alone increased c-fos as well as c-jun mRNA levels. CHXfurther enhanced KA-induced c-fos and c-jun mRNA levels. Additionally, KA increased the phosphorylation of JNK, especially JNK1, which was attenuatedby CHX, CHX decreased KA-induced c-Fos protein expression. Interestingly, CHX itself increased the phosphorylation of CREB, which was abolished by KAadministration. Our results suggest that the phosphorylation of JNK is involved in the up-regulation of the proenkephalin gene expression via c-Fos and c-Jun that is induced by KA in rat hippocampus. However, the phosphorylation of CREB is not associated with the up-regulation of the proenkephalin mRNA level induced by KA in the rat hippocampus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:38:27