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Titolo:
Rod and cone degeneration in the rd mouse is p53 independent
Autore:
Wu, J; Trogadis, J; Bremner, R;
Indirizzi:
Univ Toronto, Dept Ophthalmol, Toronto, ON M5T 2S8, Canada Univ Toronto Toronto ON Canada M5T 2S8 almol, Toronto, ON M5T 2S8, Canada Univ Toronto, Dept Lab Med, Toronto, ON M5T 2S8, Canada Univ Toronto Toronto ON Canada M5T 2S8 b Med, Toronto, ON M5T 2S8, Canada Univ Toronto, Dept Pathobiol, Toronto, ON M5T 2S8, Canada Univ Toronto Toronto ON Canada M5T 2S8 obiol, Toronto, ON M5T 2S8, Canada Toronto Western Res Inst, Univ Hlth Network, Cellular & Mol Div, Vis Sci Res Program, Toronto, ON, Canada Toronto Western Res Inst Toronto ON Canada Program, Toronto, ON, Canada
Titolo Testata:
MOLECULAR VISION
fascicolo: 15, volume: 7, anno: 2001,
pagine: 101 - 106
SICI:
1090-0535(20010426)7:15<101:RACDIT>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHOTORECEPTOR CELL-DEATH; RETINAL DEGENERATION; RETINITIS-PIGMENTOSA; CGMP PHOSPHODIESTERASE; P53-DEFICIENT MICE; HIGH-FREQUENCY; BETA-SUBUNIT; RD/RD MOUSE; APOPTOSIS; BCL-2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Bremner, R Univ Toronto, Dept Ophthalmol, 399 Bathurst St, Toronto, ON M5T2S8, Canada Univ Toronto 399 Bathurst St Toronto ON Canada M5T 2S8 , Canada
Citazione:
J. Wu et al., "Rod and cone degeneration in the rd mouse is p53 independent", MOL VIS, 7(15), 2001, pp. 101-106

Abstract

PURPOSE: To determine whether p53 is required for the death of rod and cone photoreceptors in rd mice, a model of human retinitis pigmentosa, and/or for the natural degeneration of inner nuclear layer (INL) cells in the developing retina. METHODS: Rod photoreceptor and INL apoptosis was assessed by TUNEL staining of mouse sagittal sections from post natal day (P) 10, 13, 15, 17, and 20day p53+/+ and p53-/- rd retinas. Cone photoreceptor survival was measuredby counting the total number of peanut agglutinin (PNA) positive cells in eighty four 0.25 mm x 0.25 mm bins in each eye, distributed equally across the four quadrants of whole mount retinas from 3 month old p53+/+ and p53-/- rd retinas. RESULTS: Both the kinetics of rod and INL cell death as well as the survival of cones were essentially unaffected by the absence of p53. CONCLUSIONS: Despite established links with retinal apoptosis, p53 is not essential for rod or cone cell degeneration in the rd mouse or for the elimination of bipolar and Muller cells during late retinal development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 02:00:05