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Titolo:
Pod-1/Capsulin shows a sex- and stage-dependent expression pattern in the mouse gonad development and represses expression of Ad4BP/SF-1
Autore:
Tamura, M; Kanno, Y; Chuma, S; Saito, T; Nakatsuji, N;
Indirizzi:
Natl Inst Genet, Genet Strains Res Ctr, Mammalian Dev Lab, Mishima, Shizuoka 411, Japan Natl Inst Genet Mishima Shizuoka Japan 411 , Mishima, Shizuoka 411, Japan Saitama Univ, Fac Sci, Dept Biol, Urawa, Saitama 338, Japan Saitama Univ Urawa Saitama Japan 338 Dept Biol, Urawa, Saitama 338, Japan Kyoto Univ, Inst Frontier Med Sci, Dept Dev & Differentiat, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 ferentiat, Sakyo Ku, Kyoto 6068507, Japan
Titolo Testata:
MECHANISMS OF DEVELOPMENT
fascicolo: 1-2, volume: 102, anno: 2001,
pagine: 135 - 144
SICI:
0925-4773(200104)102:1-2<135:PSASAS>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOOP-HELIX PROTEIN; MULLERIAN-INHIBITING SUBSTANCE; HORMONE-RECEPTOR SUPERFAMILY; ADRENAL HYPOPLASIA CONGENITA; SRY-RELATED GENE; TRANSCRIPTION FACTOR; NUCLEAR RECEPTOR; FTZ-F1 GENE; DNA-BINDING; UROGENITAL DEVELOPMENT;
Keywords:
sex differentiation; gonad development; basic helix-loop-helix; Pod-1/Capsulin; Ad4BP/SF-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Nakatsuji, N Natl Inst Genet, Genet Strains Res Ctr, Mammalian Dev Lab, Mishima, Shizuoka 411, Japan Natl Inst Genet Mishima Shizuoka Japan 411 izuoka 411, Japan
Citazione:
M. Tamura et al., "Pod-1/Capsulin shows a sex- and stage-dependent expression pattern in the mouse gonad development and represses expression of Ad4BP/SF-1", MECH DEVEL, 102(1-2), 2001, pp. 135-144

Abstract

Mammalian sex-determination and differentiation are controlled by several genes, such as Sry, Sox-9, Dax-1 and Mullarian inhibiting substance (MIS), but their upstream and downstream genes are largely unknown. Ad4BP/SF-1, encoding a zinc finger transcription factor, plays important roles in gonadogenesis. Disruption of this gene caused disappearance of the urogenital system including the gonad. Ad4BP/ SF-1, however, is also involved in the sex differentiation of the gonad at later stages, such as the regulation of steroid hormones and MIS. Pod-1/Capsulin, a member of basic helix-loop-helix transcription factors, is expressed in a pattern closely related but mostly complimentary to that of the Ad4BP/SF-1 expression in the developing gonad. In the co-transfection experiment using cultured cells, overexpression of Pod-1/Capsulin repressed expression of a reporter gene that carried the upstream regulatory region of the Ar4BP/SF-1 gene. Furthermore, forced expression of Pod-1/Capsulin repressed expression of Ad4BP/SF-1 in the Leydig cell derived I-10 cells. These results suggest that Pod-1/Capsulin may play important roles in the development and sex differentiation of the mammalian gonad via transcriptional regulation of Ad4BP/SF-1. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 19:52:54