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Titolo:
Homeotic Complex (Hox) gene regulation and homeosis in the mesoderm of theDrosophila melanogaster embryo: the roles of signal transduction and cell autonomous regulation
Autore:
Miller, DFB; Holtzman, SL; Kalkbrenner, A; Kaufman, TC;
Indirizzi:
Indiana Univ, Dept Biol, Howard Hughes Med Inst, Bloomington, IN 47405 USAIndiana Univ Bloomington IN USA 47405 Med Inst, Bloomington, IN 47405 USA
Titolo Testata:
MECHANISMS OF DEVELOPMENT
fascicolo: 1-2, volume: 102, anno: 2001,
pagine: 17 - 32
SICI:
0925-4773(200104)102:1-2<17:HC(GRA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
DNA-BINDING SPECIFICITY; VISCERAL MESODERM; FUNCTIONAL HIERARCHY; ENDODERM INDUCTION; ECTOPIC EXPRESSION; BITHORAX COMPLEX; MUSCLE PATTERN; SELECTOR GENE; TRANSCRIPTIONAL REPRESSION; ULTRABITHORAX EXPRESSION;
Keywords:
Drosophila melanogaster; homeotic complex; hox; homeosis; signal transduction; somatic mesoderm; visceral mesoderm; endoderm; colinearity; segmental register shift; posterior dominance; phenotypic suppression; posterior prevalence; autonomic dominance;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
119
Recensione:
Indirizzi per estratti:
Indirizzo: Kaufman, TC Indiana Univ, Dept Biol, Howard Hughes Med Inst, Bloomington, IN 47405 USA Indiana Univ Bloomington IN USA 47405 oomington, IN 47405 USA
Citazione:
D.F.B. Miller et al., "Homeotic Complex (Hox) gene regulation and homeosis in the mesoderm of theDrosophila melanogaster embryo: the roles of signal transduction and cell autonomous regulation", MECH DEVEL, 102(1-2), 2001, pp. 17-32

Abstract

In this paper we evaluate homeosis and Homeotic Complex (Hox) regulatory hierarchies in the somatic and visceral mesoderm. We demonstrate that both Hox control of signal transduction and cell autonomous regulation are critical for establishing normal Hox expression patterns and the specification ofsegmental identity and morphology. We present data identifying novel regulatory interactions associated with the segmental register shift in Hox expression domains between the epidermis/somatic mesoderm and visceral mesoderm. A proposed mechanism for the gap between the expression domains of Sex combs reduced (Scr) and Antennapedia (Antp) in the visceral mesoderm is provided. Previously, Hox gene interactions: have been shown to occur on multiple levels: direct cross-regulation, competition for binding sites at downstream targets and through indirect feedback involving signal transduction. Wefind that extrinsic specification of cell fate by signaling can be overridden by Hox protein expression in mesodermal cells and propose the term autonomic dominance for this phenomenon. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 19:50:37