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Titolo:
Assignment of the H-1 and C-13 NMR spectra, sequence and conformation of the synthetic pentasaccharide SanOrg34006 and its precursors
Autore:
Bootsma, J; Wagenaars, G; Dreef, E; Hout, F; Kellenbach, E;
Indirizzi:
Organon Labs, Dept Chem, F-63203 Zl De La Varenne, France Organon Labs ZlDe La Varenne France F-63203 03 Zl De La Varenne, France Organon Int BV, Dept Analyt Chem Dev, NL-5340 BH Oss, Netherlands Organon Int BV Oss Netherlands NL-5340 BH v, NL-5340 BH Oss, Netherlands Organon Int BV, Dept Proc Chem, NL-5340 BH Oss, Netherlands Organon Int BV Oss Netherlands NL-5340 BH m, NL-5340 BH Oss, Netherlands
Titolo Testata:
MAGNETIC RESONANCE IN CHEMISTRY
fascicolo: 5, volume: 39, anno: 2001,
pagine: 288 - 293
SICI:
0749-1581(200105)39:5<288:AOTHAC>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTITHROMBIN-III; CORRELATION SPECTROSCOPY; HEPARIN PENTASACCHARIDE; BIOLOGICAL PROPERTIES; HIGH-AFFINITY; BINDING; SENSITIVITY; FRAGMENTS; ACID; GLYCOSAMINOGLYCANS;
Keywords:
NMR; H-1 NMR; C-13 NMR; oligosaccharide; iduronic acid; conformational analysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Kellenbach, E Organon Labs, Dept Chem, 22 Rue H Goudier,BP 140 Riom, F-63203 Zl De La Varenne, France Organon Labs 22 Rue H Goudier,BP 140 Riom Zl DeLa Varenne France F-63203
Citazione:
J. Bootsma et al., "Assignment of the H-1 and C-13 NMR spectra, sequence and conformation of the synthetic pentasaccharide SanOrg34006 and its precursors", MAGN RES CH, 39(5), 2001, pp. 288-293

Abstract

Proton and carbon chemical shift data and proton-proton coupling constantsof the synthetic antithrombotic pentasaccharide SanOrg34006 and its synthetic precursors are reported. Long-range heteronuclear correlation experiments allow the determination of the substitution pattern of the protecting groups in the precursor molecules. Also, the sequence of the oligosaccharide was confirmed this way. The conformation of the alpha -L-iduronic acid moiety was studied by the analysis of the (3)J(H-1,H-1) coupling constants. Copyright (C) 2001 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 19:18:33