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Titolo:
Postreperfusion biopsies are useful in predicting complications after liver transplantation
Autore:
Busquets, J; Figueras, J; Serrano, T; Torras, J; Ramos, E; Rafecas, A; Fabregat, J; Lama, C; Xiol, X; Baliellas, C; Jaurrieta, E;
Indirizzi:
Univ Barcelona, Ciudad Sanitaria & Univ Bellvitge, Hosp Princeps Espanya, Serv Cirugia Gen & Digest,Dept Surg, Barcelona 08907, Spain Univ BarcelonaBarcelona Spain 08907 t,Dept Surg, Barcelona 08907, Spain Univ Barcelona, Ciudad Sanitaria & Univ Bellvitge, Hosp Princeps Espanya, Dept Pathol, Barcelona 08907, Spain Univ Barcelona Barcelona Spain 08907 Dept Pathol, Barcelona 08907, Spain Univ Barcelona, Ciudad Sanitaria & Univ Bellvitge, Hosp Princeps Espanya, Dept Gastroenterol, Barcelona 08907, Spain Univ Barcelona Barcelona Spain08907 stroenterol, Barcelona 08907, Spain
Titolo Testata:
LIVER TRANSPLANTATION
fascicolo: 5, volume: 7, anno: 2001,
pagine: 432 - 435
SICI:
1527-6465(200105)7:5<432:PBAUIP>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
UW SOLUTION; INTRAOPERATIVE BIOPSIES; GRAFT FUNCTION; COLD ISCHEMIA; PRESERVATION; INJURY; DONOR; ALLOGRAFTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Figueras, J Univ Barcelona, Ciudad Sanitaria & Univ Bellvitge, Hosp Princeps Espanya, Serv Cirugia Gen & Digest,Dept Surg, C Feixa Llarga S-N, Barcelona 08907, Spain Univ Barcelona C Feixa Llarga S-N Barcelona Spain 08907 Spain
Citazione:
J. Busquets et al., "Postreperfusion biopsies are useful in predicting complications after liver transplantation", LIVER TRANS, 7(5), 2001, pp. 432-435

Abstract

Biliary complications after orthotopic liver transplantation (OLT) may occur because of preservation injury (PI), In this study, we examine findings on routine reperfusion biopsy specimens in relation to the occurrence of biliary complications and graft outcome. From 1997 to 2000, a total of 193 OLTs were performed in our center, Postreperfusion biopsy specimens were analyzed and histological lesions were graded. For analysis, grafts were grouped into 2 categories: the presence or absence of PI (severe to moderate lesions versus mild or no lesions), Histological evidence of PI was present in 17% of the biopsy specimens. The incidence of grafts with PI and ischemia time longer than 12 hours was 38% compared with 14% in PI and short ischemiatime (P =,02), Biliary complications were also more frequent in the PI group (28% v 14%; P =,03), Study of risk factors by means of logistic regression analysis confirmed that the PI group had a greater risk for biliary complications (relative risk, 2.8; 95% confidence interval, 1 to 7.4; P =,03), Moreover, moderate macrovesicular steatosis was found in 6% of the grafts, resulting in a 40% graft loss rate. We found that an increased presence of neutrophilic infiltrates in the postreperfusion biopsy specimen, indicatingPI, was related to an increased incidence of biliary complications. Moreover, moderate macrovesicular steatosis was associated with increased graft loss. Therefore, postreperfusion biopsies are useful in anticipating post-OLT complications.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 16:05:27