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Titolo:
Elucidating the role of muscarinic receptors in psychosis
Autore:
Felder, CC; Porter, AC; Skillman, TL; Zhang, L; Bymaster, FP; Nathanson, NM; Hamilton, SE; Gomeza, J; Wess, J;
Indirizzi:
Lilly Corp Ctr, Eli Lilly Res Labs, Div Neurosci, Indianapolis, IN 46285 USA Lilly Corp Ctr Indianapolis IN USA 46285 osci, Indianapolis, IN 46285 USA Univ Washington, Sch Med, Dept Pharmacol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ept Pharmacol, Seattle, WA 98195 USA NIDDK, Lab Bioorgan Chem, Bethesda, MD 20892 USA NIDDK Bethesda MD USA 20892 DK, Lab Bioorgan Chem, Bethesda, MD 20892 USA
Titolo Testata:
LIFE SCIENCES
fascicolo: 22-23, volume: 68, anno: 2001,
pagine: 2605 - 2613
SICI:
0024-3205(20010427)68:22-23<2605:ETROMR>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
KNOCKOUT MICE; HYPOTHESIS; AGONISTS; CELLS;
Keywords:
muscarinic receptor subtypes; cognition; psychosis; GTP binding; startle reflex; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Felder, CC Lilly Corp Ctr, Eli Lilly Res Labs, Div Neurosci, Drop 0510, Indianapolis,IN 46285 USA Lilly Corp Ctr Drop 0510 Indianapolis IN USA 46285 IN 46285 USA
Citazione:
C.C. Felder et al., "Elucidating the role of muscarinic receptors in psychosis", LIFE SCI, 68(22-23), 2001, pp. 2605-2613

Abstract

Muscarinic receptors have been implicated in the regulation of cognition and psychosis based on pharmacological evidence from pre-clinical and clinical studies. Muscarinic agonists have shown promise in the clinic in improving cognition and reducing psychotic episodes in Alzheimer's patients. However, lack of selective muscarinic ligands has limited their use due to troublesome side effects observed at higher doses. Without selective ligands, ithas been difficult to assign a specific muscarinic receptor subtype to these high order mental processes. Recent development of muscarinic receptor knockout mice has provided additional tools to investigate cognition and psychosis in behavioral assays and to determine the receptor subtypes associated with parasympathomimetic physiology. Biochemical studies indicate that the M-1 receptor plays a significant role in regulating G alphaq-mediated signal transduction in the hippocampus and cortex. Behavioral studies suggestthat the M-4 receptor is involved in movement regulation and prepulse inhibition of the startle reflex, a measure of attention. These findings support a role for the development of M-1 and M-4 receptor agonists for diseases in which symptoms include cognitive impairment and psychotic behaviors. (C)2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:37:29