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Titolo:
The conformational switch in muscarinic acetylcholine receptors
Autore:
Hulme, EC; Lu, ZL; Bee, M; Curtis, CAM; Saldanha, J;
Indirizzi:
Natl Inst Med Res, London NW7 1AA, England Natl Inst Med Res London England NW7 1AA ed Res, London NW7 1AA, England
Titolo Testata:
LIFE SCIENCES
fascicolo: 22-23, volume: 68, anno: 2001,
pagine: 2495 - 2500
SICI:
0024-3205(20010427)68:22-23<2495:TCSIMA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-COUPLED RECEPTORS; SCANNING MUTAGENESIS; RHODOPSIN;
Keywords:
muscarinic; acetylcholine; G-protein; rhodopsin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Hulme, EC Natl Inst Med Res, The Ridgeway,Mill Hill, London NW7 1AA, England Natl Inst Med Res The Ridgeway,Mill Hill London England NW7 1AA
Citazione:
E.C. Hulme et al., "The conformational switch in muscarinic acetylcholine receptors", LIFE SCI, 68(22-23), 2001, pp. 2495-2500

Abstract

The recently-determined structure of rhodopsin has provided a suitable basis for modeling the three-dimensional structure of the M-1 muscarinic acetylcholine receptor. Using this as a framework for interpreting mutagenesis studies, we have been able to suggest most of the contacts which the receptor makes with acetylcholine and many of the intramolecular contacts which are important for the groundstate structure of the receptor. It is possible to outline a mechanism of G-protein interaction. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 05:27:45