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Titolo:
Alteration of cardiovascular and neuronal function in M-1 knockout mice
Autore:
Hamilton, SE; Hardouin, SN; Anagnostaras, SG; Murphy, CG; Richmond, KN; Silva, AJ; Feigl, EO; Nathanson, NM;
Indirizzi:
Univ Washington, Dept Pharmacol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ept Pharmacol, Seattle, WA 98195 USA Univ Washington, Dept Physiol & Biophys, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 iol & Biophys, Seattle, WA 98195 USA Univ Calif Los Angeles, Dept Neurobiol, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA
Titolo Testata:
LIFE SCIENCES
fascicolo: 22-23, volume: 68, anno: 2001,
pagine: 2489 - 2493
SICI:
0024-3205(20010427)68:22-23<2489:AOCANF>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUSCARINIC RECEPTOR; REPRESENTATIONAL MEMORY; INVOLVEMENT; MODULATION;
Keywords:
seizure; gene targeting; learning; electrocardiogram; potassium channel; sympathetic neurons; MAP kinase; phospolipase C;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Nathanson, NM Univ Washington, Dept Pharmacol, Box 357750, Seattle, WA 98195 USA Univ Washington Box 357750 Seattle WA USA 98195 WA 98195 USA
Citazione:
S.E. Hamilton et al., "Alteration of cardiovascular and neuronal function in M-1 knockout mice", LIFE SCI, 68(22-23), 2001, pp. 2489-2493

Abstract

We used gene targeting to generate mice lacking the M, muscarinic acetylcholine receptor. These mice exhibit a decreased susceptibility to pilocarpine-induced seizures, loss of regulation of M-current potassium channel activity and of a specific calcium channel pathway in sympathetic neurons, a loss of the positive chronotropic acid inotropic responses to the novel muscarinic agonist McN-A-343, and impaired learning in a hippocampal-dependent test of spatial memory. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 06:50:08