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Titolo:
Identification of subtypes of muscarinic receptors that regulate Ca2+ and K+ channel activity in sympathetic neurons
Autore:
Shapiro, MS; Gomeza, J; Hamilton, SE; Hille, B; Loose, MD; Nathanson, NM; Roche, JP; Wess, J;
Indirizzi:
Univ Washington, Sch Med, Dept Physiol & Biophys, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 iol & Biophys, Seattle, WA 98195 USA Univ Washington, Sch Med, Dept Pharmacol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ept Pharmacol, Seattle, WA 98195 USA Oberlin Coll, Program Neurosci, Oberlin, OH 44074 USA Oberlin Coll Oberlin OH USA 44074 Program Neurosci, Oberlin, OH 44074 USA NIDDKD, Bioorgan Chem Lab, NIH, Bethesda, MD 20892 USA NIDDKD Bethesda MDUSA 20892 oorgan Chem Lab, NIH, Bethesda, MD 20892 USA
Titolo Testata:
LIFE SCIENCES
fascicolo: 22-23, volume: 68, anno: 2001,
pagine: 2481 - 2487
SICI:
0024-3205(20010427)68:22-23<2481:IOSOMR>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CALCIUM CHANNELS; VOLTAGE DEPENDENCE; CURRENT INHIBITION; KNOCKOUT MICE; N-TYPE; ACTIVATION; MODULATION; NEUROTRANSMITTERS; SUPPRESSION; DISRUPTION;
Keywords:
muscarinic receptor; G protein; Ca2+ channel; M current;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Shapiro, MS Univ Texas, Hlth Sci Ctr, Dept Physiol, MS 7756,7703 Floyd Curl Dr, San Antonio, TX 78229 USA Univ Texas MS 7756,7703 Floyd Curl Dr San Antonio TX USA 78229
Citazione:
M.S. Shapiro et al., "Identification of subtypes of muscarinic receptors that regulate Ca2+ and K+ channel activity in sympathetic neurons", LIFE SCI, 68(22-23), 2001, pp. 2481-2487

Abstract

Many different G protein-coupled receptors modulate the activity of Ca2+ and K+ channels in a variety of neuronal types. There art: five known subtypes (M-1-M-5) Of muscarinic acetylcholine receptors. Knockout mice lacking the M-1, M-2, or M-4 subtypes are studied to determine which receptors mediate modulation of voltage-gated Ca2+ channels in mouse sympathetic neurons. In these cells, muscarinic agonists modulate N- and L-type Ca2+ channels and the M-type K+ channel through two distinct, G-protein mediated pathways. The fast and voltage-dependent pathway is lacking in the M-2 receptor knockout mice. The slow acid voltage-independent pathway is absent in the M-1 receptor knockout mice. Neither pathway is affected in the M-4 receptor knockout mice. Muscarinic modulation of the M current is absent in the M-1 receptor knockout mice, and can be reconstituted in a heterologous expression system using cloned channels and M-1 receptors. Our results using knockout mice are compared with pharmacological data in the rat. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/11/20 alle ore 20:26:24