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Titolo:
Role of the M-1 receptor in regulating circadian rhythms
Autore:
Gillette, MU; Buchanan, GF; Artinian, L; Hamilton, SE; Nathanson, NM; Liu, C;
Indirizzi:
Univ Illinois, Dept Cell & Struct Biol, Urbana, IL 61801 USA Univ Illinois Urbana IL USA 61801 ell & Struct Biol, Urbana, IL 61801 USA Univ Illinois, Dept Mol & Integrat Physiol, Urbana, IL 61801 USA Univ Illinois Urbana IL USA 61801 Integrat Physiol, Urbana, IL 61801 USA Univ Illinois, Neurosci Program, Urbana, IL 61801 USA Univ Illinois Urbana IL USA 61801 Neurosci Program, Urbana, IL 61801 USA Univ Illinois, Coll Med, Urbana, IL 61801 USA Univ Illinois Urbana IL USA61801 llinois, Coll Med, Urbana, IL 61801 USA Univ Washington, Sch Med, Dept Pharmacol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ept Pharmacol, Seattle, WA 98195 USA
Titolo Testata:
LIFE SCIENCES
fascicolo: 22-23, volume: 68, anno: 2001,
pagine: 2467 - 2472
SICI:
0024-3205(20010427)68:22-23<2467:ROTMRI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUPRACHIASMATIC BRAIN SLICE; MUSCARINIC RECEPTORS; SYRIAN-HAMSTERS; PHASE-SHIFTS; RAT; NUCLEUS; NEURONS; CLOCK; LIGHT; ACETYLCHOLINE;
Keywords:
acetylcholine; cGMP/PKG signaling; circadian rhythms; muscarinic receptors; suprachiasmatic nucleus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Gillette, MU Univ Illinois, Dept Cell & Struct Biol, MC-123,B107,CLSL,601 S Goodwin Ave, Urbana, IL 61801 USA Univ Illinois MC-123,B107,CLSL,601 S Goodwin Ave Urbana IL USA 61801
Citazione:
M.U. Gillette et al., "Role of the M-1 receptor in regulating circadian rhythms", LIFE SCI, 68(22-23), 2001, pp. 2467-2472

Abstract

Cholinergic stimuli are potent regulators of the circadian clock in the hypothalamic suprachiasmatic nucleus (SCN). Using a brain slice model, we have found that the SCN clock is subject to muscarinic regulation, a sensitivity expressed only during the night of the clock's 24-h cycle. Pharmacological and signal transduction characteristics are compatible with a response mediated by an M-1-like receptor. Molecular manipulation of muscarinic receptors will provide important insights as to the receptor subtype(s) regulating circadian rhythms. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 07:33:09