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Titolo:
LYMPHOMAS IN PATIENTS WITH SJOGRENS-SYNDROME ARE MARGINAL ZONE B-CELLNEOPLASMS, ARISE IN DIVERSE EXTRANODAL AND NODAL SITES, AND ARE NOT ASSOCIATED WITH VIRUSES
Autore:
ROYER B; CAZALSHATEM D; SIBILIA J; AGBALIKA F; CAYUELA JM; SOUSSI T; MALOISEL F; CLAUVEL JP; BROUET JC; MARIETTE X;
Indirizzi:
HOP ST LOUIS,SERV IMMUNOHEMATOL,1 AVE CLAUDE VELLEFAUX F-75475 PARIS 10 FRANCE HOP ST LOUIS,SERV IMMUNOHEMATOL F-75475 PARIS 10 FRANCE HOP ST LOUIS,LAB ANATOMOPATHOL F-75475 PARIS 10 FRANCE HOP ST LOUIS,SERV BACTERIOVIROL F-75475 PARIS 10 FRANCE HOP ST LOUIS,INSERM U93 IMMUNOGENET TRANSPLANTAT F-75475 PARIS 10 FRANCE HOP ST LOUIS,U301 INSERM GENET CELLULAIRE & MOL LEUCEMIES,IGM F-75475PARIS 10 FRANCE HOP HAUTE PIERRE,SERV HEMATOL STRASBOURG FRANCE
Titolo Testata:
Blood
fascicolo: 2, volume: 90, anno: 1997,
pagine: 766 - 775
SICI:
0006-4971(1997)90:2<766:LIPWSA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPSTEIN-BARR-VIRUS; POLYMERASE CHAIN-REACTION; SALIVARY-GLAND BIOPSIES; NON-HODGKINS-LYMPHOMAS; HIGH-GRADE LYMPHOMA; HEPATITIS-C VIRUS; I TAX GENE; MALIGNANT-LYMPHOMA; TISSUE LYMPHOMA; LYMPHOPROLIFERATIVE DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
62
Recensione:
Indirizzi per estratti:
Citazione:
B. Royer et al., "LYMPHOMAS IN PATIENTS WITH SJOGRENS-SYNDROME ARE MARGINAL ZONE B-CELLNEOPLASMS, ARISE IN DIVERSE EXTRANODAL AND NODAL SITES, AND ARE NOT ASSOCIATED WITH VIRUSES", Blood, 90(2), 1997, pp. 766-775

Abstract

The occurrence of non-Hodgkin's lymphoma (NHL) is the most serious complication of Sjogren's syndrome (SS), We performed a study of 16 NHLsoccurring in patients with an underlying SS. These lymphomas arose not only in salivary glands (7 cases) but also in other mucosal extranodal sites (the stomach [4 cases], the lung [3 cases], the skin [3 cases], the buccal mucosa [1 case], the thymus [1 case]) and in nodal sites(8 cases), Low-grade marginal zone lymphomas (MZL) were diagnosed in 12 of the 16 patients, 9 of mucosa-associated lymphoid tissues (MALT) type in mucosal sites and 3 exclusively nodal, The 4 other patients presented with a high-grade B-cell lymphoma that was probably a histological transformation of an underlying low-grade MZL at least in 3 of the cases involving skin, stomach, and parotid, respectively, A t(14;18)translocation was detected in 1 of 8 lymphomas tested. We detected serum anti-p53 antibodies in 2 of the 14 studied patients, p53 protein was detected in 1 of 11 lymphomas tested, LMP protein and Eber RNAs of Epstein-Barr virus (EBV) were not detected in the 16 NHL biopsies. Using polymerase chain reaction, EBV was never detected except in 1 of 4 parotid lymphomas. No human T-lymphotropic virus 1 or human herpes virus 8 DNAs were detected in NHL biopsies, None of the patients had hepatitis C virus infection found using serological methods. Chemotherapy was usually efficient. In conclusion, lymphomas occurring in patients with an underlying SS are in most cases MZL, These lymphomas are not associated with viruses known to be present in other types of lymphomas, Some of the translocations or mutations of oncogenes or antioncogenes described in other lymphomas are detected in SS-associated lymphomas. (C) 1997 by The American Society of Hematology.

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Documento generato il 02/12/20 alle ore 18:08:04