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Titolo:
Carcinogenesis of cancer of the papilla and ampulla: pathophysiological facts and molecular biological mechanisms
Autore:
Esposito, I; Friess, H; Buchler, MW;
Indirizzi:
Univ Bern, Inselspital, Dept Visceral & Transplantat Surg, CH-3010 Bern, Switzerland Univ Bern Bern Switzerland CH-3010 antat Surg, CH-3010 Bern, Switzerland
Titolo Testata:
LANGENBECKS ARCHIVES OF SURGERY
fascicolo: 3, volume: 386, anno: 2001,
pagine: 163 - 171
SICI:
1435-2443(200104)386:3<163:COCOTP>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN PANCREATIC-CANCER; FAMILIAL ADENOMATOUS POLYPOSIS; GROWTH-FACTOR-BETA; FREQUENT SOMATIC MUTATIONS; RAS ONCOGENE ACTIVATION; 67-KD LAMININ RECEPTOR; GENE-MUTATIONS; P53 MUTATIONS; GASTRIC-CANCER; CELL-CYCLE;
Keywords:
carcinogenesis; ampullary cancer; papilla;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
97
Recensione:
Indirizzi per estratti:
Indirizzo: Friess, H Univ Bern, Inselspital, Dept Visceral & Transplantat Surg, CH-3010 Bern, Switzerland Univ Bern Bern Switzerland CH-3010 , CH-3010 Bern, Switzerland
Citazione:
I. Esposito et al., "Carcinogenesis of cancer of the papilla and ampulla: pathophysiological facts and molecular biological mechanisms", LANG ARCH S, 386(3), 2001, pp. 163-171

Abstract

Background. Ampullary cancer has one of the highest resectability rates and best prognoses among neoplasms arising in the periampullary region. Discussion: Early diagnosis due to early symptoms can partially explain the better prognosis as compared to other cancers of the periampullary region, but biologic factors should also be taken in account. In the past few years, the molecular mechanisms underlying this disease have been investigated and alterations of genes that regulate different cell functions have been described. Mutations of K-ras and of the tumor suppressor genes APC, p16 and p53 indicate a major disturbance in cell cycle regulation. Conclusions: If the molecular profile of ampullary cancer is examined in terms of rate and typeof molecular changes, it seems to be more similar to intestinal than to pancreatic cancer. Furthermore, the fact that many ampullary carcinomas arisefrom adenomas and the frequent finding of ampullary tumors in patients affected by polyposis syndromes also suggest that ampullary and colon cancers share common molecular mechanisms of carcinogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 07:00:00