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Titolo:
A simplified method for determination of tetrabromobisphenol A and polybrominated diphenyl ethers in human plasma and serum
Autore:
Thomsen, C; Lundanes, E; Becher, G;
Indirizzi:
Natl Inst Publ Hlth, N-0403 Oslo, Norway Natl Inst Publ Hlth Oslo NorwayN-0403 st Publ Hlth, N-0403 Oslo, Norway Univ Oslo, Dept Chem, N-0315 Oslo, Norway Univ Oslo Oslo Norway N-0315Univ Oslo, Dept Chem, N-0315 Oslo, Norway Norwegian Inst Water Res, N-0411 Oslo, Norway Norwegian Inst Water Res Oslo Norway N-0411 ter Res, N-0411 Oslo, Norway
Titolo Testata:
JOURNAL OF SEPARATION SCIENCE
fascicolo: 4, volume: 24, anno: 2001,
pagine: 282 - 290
SICI:
1615-9314(200104)24:4<282:ASMFDO>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
BROMINATED FLAME RETARDANTS; SWEDISH HUMAN-MILK; SPLITLESS INJECTION; POLLUTANTS; PESTICIDES; RIVER; FISH;
Keywords:
brominated flame retardants; human plasma and serum; SPE; GC-ECMS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Thomsen, C Natl Inst Publ Hlth, POB 4404 Nydalen, N-0403 Oslo, Norway NatlInst Publ Hlth POB 4404 Nydalen Oslo Norway N-0403 Norway
Citazione:
C. Thomsen et al., "A simplified method for determination of tetrabromobisphenol A and polybrominated diphenyl ethers in human plasma and serum", J SEP SCI, 24(4), 2001, pp. 282-290

Abstract

A method utilizing solid-phase extraction (SPE) and gas chromatography with electron capture mass spectrometric detection (GC-ECMS) has been developed for simultaneous determination of seven polybrominated diphenyl ethers (PBDEs) and tetrabromobisphenol A (TBBP-A) in plasma and serum. Plasma and serum samples of 5.0 g were diluted and applied to a polystyrene-divinylbenzene SPE column. The lipids were decomposed by treatment with concentrated sulfuric acid directly on the SPE column, prior to elution of the brominated flame retardants by dichloromethane-methanol (7 + 3, v/v). Following diazomethane derivatization, the samples were analyzed by GC-ECMS. The method hasbeen validated in the concentration range of 1.8-90 pg brominated flame retardants/g plasma or serum. The average absolute recoveries were in the range of 56-111% and 40-90% for plasma and serum, respectively. The average recoveries of the analytes relative to the internal standards were 75-108% and 88-111% for plasma and serum, respectively. The repeatability of the method was in the range of 0.6-27% RSD, and the estimated detection limits werein the range of 0.4-9.8 pg/g plasma or serum. The human plasma used for validation contained all the investigated analytes, in concentrations below 4ng/g lipid weight.

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Documento generato il 19/01/20 alle ore 21:09:40