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Titolo:
Analysis of guaifenesin-based cough syrups by micellar electrokinetic chromatography and GC-MS
Autore:
Pomponio, R; Gotti, R; Hudaib, M; Andrisano, V; Cavrini, V;
Indirizzi:
Univ Bologna, Dipartimento Sci Farmaceut, I-40126 Bologna, Italy Univ Bologna Bologna Italy I-40126 Sci Farmaceut, I-40126 Bologna, Italy
Titolo Testata:
JOURNAL OF SEPARATION SCIENCE
fascicolo: 4, volume: 24, anno: 2001,
pagine: 258 - 264
SICI:
1615-9314(200104)24:4<258:AOGCSB>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAPILLARY-ELECTROPHORESIS; DRUGS;
Keywords:
cough syrups; capillary electrophoresis; GC-MS; guaifenesin; salbutamol; dextromethorphan;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Gotti, R Univ Bologna, Dipartimento Sci Farmaceut, Via Belmeloro 6, I-40126 Bologna, Italy Univ Bologna Via Belmeloro 6 Bologna Italy I-40126 ologna, Italy
Citazione:
R. Pomponio et al., "Analysis of guaifenesin-based cough syrups by micellar electrokinetic chromatography and GC-MS", J SEP SCI, 24(4), 2001, pp. 258-264

Abstract

Capillary electrophoretic methods, under MEKC conditions, were developed for the simultaneous rapid analysis of neutral (guaifenesin) and basic (salbutamol and dextromethorphan) active ingredients of commercially available cough syrups. The running buffer nature played a key role on the migration of the studied analytes: using 0.04 M sodium dodecyl sulfate (SDS) as surfactant, sodium tetraborate and 3-(cyclohexylamino)-2-hydroxy-1 -propane-sulfonic acid sodium salt (CAPSO) were chosen as running buffer allowing the separation of active ingredients and excipients of different cough syrups. Qualitative and quantitative information on the composition of the analyzed formulations were simultaneously obtained for both active ingredients and excipients by the proposed MEKC methods; when syrups containing volatile UV-nonabsorbing components (flavors) were analyzed a CC-MS approach was chosen. The aqueous matrices of the formulations allowed direct sample injection inCE, while extraction procedures were applied in order to perform GC analyses. The obtained data support the suitability of MEKC and CC-MS as effective, complementary techniques for the selective and sensitive quality controlof cough syrups.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 01:45:35