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Titolo:
Reduced activation and expression of ERK1/2 MAP kinase in the post-mortem brain of depressed suicide subjects
Autore:
Dwivedi, Y; Rizavi, HS; Roberts, RC; Conley, RC; Tamminga, CA; Pandey, GN;
Indirizzi:
Univ Illinois, Dept Psychiat, Inst Psychiat, Chicago, IL 60612 USA Univ Illinois Chicago IL USA 60612 , Inst Psychiat, Chicago, IL 60612 USA Maryland Psychiat Res Ctr, Baltimore, MD 21228 USA Maryland Psychiat Res Ctr Baltimore MD USA 21228 Baltimore, MD 21228 USA
Titolo Testata:
JOURNAL OF NEUROCHEMISTRY
fascicolo: 3, volume: 77, anno: 2001,
pagine: 916 - 928
SICI:
0022-3042(200105)77:3<916:RAAEOE>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-TYROSINE-PHOSPHATASE; SIGNAL-TRANSDUCTION PATHWAY; PHOSPHOLIPASE-C ACTIVITY; RAT-BRAIN; PHOSPHATIDYLINOSITOL 3-KINASE; NEUROTROPHIC FACTOR; REGULATED KINASES; MOLECULAR-CLONING; PREFRONTAL CORTEX; POSTMORTEM BRAIN;
Keywords:
depression; ERK1/2; human post-mortem brain; MKP2; p42/44 MAP kinases; suicide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Dwivedi, Y Univ Illinois, Dept Psychiat, Inst Psychiat, 1601 W Taylor St, Chicago, IL60612 USA Univ Illinois 1601 W Taylor St Chicago IL USA 60612 IL60612 USA
Citazione:
Y. Dwivedi et al., "Reduced activation and expression of ERK1/2 MAP kinase in the post-mortem brain of depressed suicide subjects", J NEUROCHEM, 77(3), 2001, pp. 916-928

Abstract

The extracellular regulated kinases (ERK) 1 and ERK2 are members of mitogen-activated protein (MAP) kinase family that play an important role in transducing extracellular signals to the nucleus and have been implicated in a broad spectrum of biological responses. To test the hypothesis that MAP kinases may be involved in depression, we examined the activation of p44/42 MAP kinase and expression of ERK1 and ERK2 in the post-mortem brain tissue obtained from non-psychiatric control subjects (n = 11) and age- and the post-mortem interval-matched depressed suicide subjects (n = 11). We observed that p44/42 MAP kinase activity was significantly decreased in the prefrontal cortical areas (Brodmann's areas 8, 9 and 10) and the hippocampus of depressed suicide subjects without any change in the cerebellum. This decrease was associated with a decrease in mRNA and protein levels of ERK1 and ERK2. In addition, the expression of MAP kinase phosphatase (MKP)P, a 'dual function' ERK1/2 phosphatase, was increased in the prefrontal cortex and hippocampus. These studies suggest that p44/42 MAP kinases are less activated in the post-mortem brain of depressed suicide subjects and this may be becauseof reduced expression of ERK1/2 and increased expression of MKP2. Given the role of MAP kinases in various physiological functions and gene expression, alterations in p44/42 MAP kinase activation and expression of ERK1/2 maycontribute significantly to the pathophysiology of depressive disorders.

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Documento generato il 05/12/20 alle ore 01:50:42