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Titolo:
Identification of a novel member of the T1R family of putative taste receptors
Autore:
Sainz, E; Korley, JN; Battey, JF; Sullivan, SL;
Indirizzi:
NIDCD, Mol Biol Lab, NIH, Rockville, MD 20850 USA NIDCD Rockville MD USA 20850 , Mol Biol Lab, NIH, Rockville, MD 20850 USA
Titolo Testata:
JOURNAL OF NEUROCHEMISTRY
fascicolo: 3, volume: 77, anno: 2001,
pagine: 896 - 903
SICI:
0022-3042(200105)77:3<896:IOANMO>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
METABOTROPIC GLUTAMATE RECEPTORS; PHEROMONE RECEPTORS; CA2+-SENSING RECEPTOR; OLFACTORY EPITHELIUM; MULTIGENE FAMILY; ODORANT RECEPTOR; MICE; EXPRESSION; TRANSDUCTION; SACCHARIN;
Keywords:
G protein-coupled receptor; gustation; gustatory system; mouse; Sac locus; taste;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Sullivan, SL NIDCD, Mol Biol Lab, NIH, 5 Res Court, Rockville, MD 20850 USA NIDCD 5 Res Court Rockville MD USA 20850 kville, MD 20850 USA
Citazione:
E. Sainz et al., "Identification of a novel member of the T1R family of putative taste receptors", J NEUROCHEM, 77(3), 2001, pp. 896-903

Abstract

In the gustatory system, the recognition of sugars, amino acids and bitter-tasting compounds is the function of specialized G rotein-coupled receptors. Recently, two members of novel subfamily of G protein-coupled receptors were proposed to function as taste receptors based on their specific expression in taste receptor cells. Here, we report the identification of a thirdmember, T1R3, of this family of receptors. T1R3 maps near the telomere of mouse chromosome 4 rendering it a candidate for the Sac locus, a primary determinant of sweet preference in mice. Consistent with its candidacy for the Sac locus, T1R3 displays taste receptor cell-specific expression. In addition, taster and non-taster strains of mouse harbor different alleles of T1R3.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 05:53:43