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Titolo:
Dehydroepiandrosterone inhibits lipopolysaccharide-induced nitric oxide production in BV-2 microglia
Autore:
Wang, MJ; Huang, HM; Chen, HL; Jeng, KCG;
Indirizzi:
Taichung Vet Gen Hosp, Dept Educ & Res, Taichung 40705, Taiwan Taichung Vet Gen Hosp Taichung Taiwan 40705 Res, Taichung 40705, Taiwan
Titolo Testata:
JOURNAL OF NEUROCHEMISTRY
fascicolo: 3, volume: 77, anno: 2001,
pagine: 830 - 838
SICI:
0022-3042(200105)77:3<830:DILNOP>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
NF-KAPPA-B; CENTRAL-NERVOUS-SYSTEM; OXIDATIVE STRESS; SUPEROXIDE GENERATION; TRANSCRIPTION FACTOR; CULTURED ASTROCYTES; CYTOKINE INDUCTION; DEPENDENT PATHWAY; GLIAL-CELLS; HUMAN-BRAIN;
Keywords:
dehydroepiandrosterone; inducible nitric oxide synthase; lipopolysaccharide; microglia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Jeng, KCG Taichung Vet Gen Hosp, Dept Educ & Res, Taichung 40705, Taiwan Taichung Vet Gen Hosp Taichung Taiwan 40705 hung 40705, Taiwan
Citazione:
M.J. Wang et al., "Dehydroepiandrosterone inhibits lipopolysaccharide-induced nitric oxide production in BV-2 microglia", J NEUROCHEM, 77(3), 2001, pp. 830-838

Abstract

Levels of dehydroepiandrosterone (DHEA) and its sulfated derivative (DHEAS) decline during aging and reach even lower levels in Alzheimer's disease (AD). DHEA is known to exhibit a variety of functional activities in the CNS, including an increase of memory and learning, neurotrophic and neuroprotective effects, and the reduction of risk of age-related neurodegenerative disorders. However, the influence of DHEA on the immune functions of glial cells is poorly understood. In this study, we investigated the effect of DHEA on activated glia. The production of inducible nitric oxide synthase (iNOS) was studied in lipopolysaccharide (LPS)stimulated BV-2 microglia, as a model of glial activation. The results showed that DHEA but not DHEAS significantly inhibited the production of nitrite in the LPS-stimulated BV-2 cellcultures. Pretreatment of BV-2 cells with DHEA reduced the LPS-induced iNOS mRNA and protein levels in a dose-dependent manner. The LPS-induced iNOS activity in BV-2 cells was decreased by the exposure of 100 muM DHEA. Moreover, DHEA suppressed iNOS gene expression in LPS-stimulated BV-2 cells did not require de novo synthesis of new proteins or destabilize of iNOS mRNA. Since DHEA is biosynthesized by astrocytes and neurons, our findings suggest that it might have an important regulatory function on microglia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 16:45:30