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Titolo:
Control of serotonergic neurons in rat brain by dopaminergic receptors outside the dorsal raphe nucleus
Autore:
Martin-Ruiz, R; Ugedo, L; Honrubia, MA; Mengod, G; Artigas, F;
Indirizzi:
CSIC, IDIBAPS, IIBB, Dept Neurochem, Barcelona 08036, Spain CSIC Barcelona Spain 08036 IIBB, Dept Neurochem, Barcelona 08036, Spain Univ Basque Country, Sch Med, Dept Pharmacol, Leioa, Spain Univ Basque Country Leioa Spain , Sch Med, Dept Pharmacol, Leioa, Spain
Titolo Testata:
JOURNAL OF NEUROCHEMISTRY
fascicolo: 3, volume: 77, anno: 2001,
pagine: 762 - 775
SICI:
0022-3042(200105)77:3<762:COSNIR>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRAL TEGMENTAL AREA; INSITU HYBRIDIZATION HISTOCHEMISTRY; IN-VIVO MICRODIALYSIS; FREELY MOVING RATS; SUBSTANTIA-NIGRA; ELECTRICAL-STIMULATION; SELECTIVE LIGANDS; 5-HT3 RECEPTOR; D-2 RECEPTORS; MESSENGER-RNA;
Keywords:
DA receptors; extracellular recordings; 5-hydroxytryptamine release; 5-HT1A receptors; in situ hybridization; microdialysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Artigas, F CSIC, IDIBAPS, IIBB, Dept Neurochem, Rossello 161, Barcelona 08036, Spain CSIC Rossello 161 Barcelona Spain 08036 Barcelona 08036, Spain
Citazione:
R. Martin-Ruiz et al., "Control of serotonergic neurons in rat brain by dopaminergic receptors outside the dorsal raphe nucleus", J NEUROCHEM, 77(3), 2001, pp. 762-775

Abstract

We studied the control of dorsal raphe (DR) serotonergic neurons by dopaminergic transmission in rat brain using microdialysis and single unit extracellular recordings. Apomorphine (0.5-3.0 mg/kg s.c.) and quinpirole (0.5 mg/kg s.c.) increased serotonin (5-HT) output in the DR and (only apomorphine) in striatum. These effects were antagonized by 0.3 mg/kg s.c. SCH 23390 (in DR and striatum) and 1 mg/kg s.c. raclopride (in DR). 5-HT1A receptor blockade potentiated the 5-HT increase produced by apomorphine in the DR. Apomorphine (50-400 mug/kg i.v.) increased the firing rate of most 5-HT neurons, an effect prevented by SCH 23390 and raclopride. Quinpirole (40-160 mug/kg i.v.) also enhanced the firing rate of 5-HT neurons. When applied in theDR, neither drug increased the 5-HT output in the DR or striatum. Likewise, micropressure injection of quinpirole (0.2-8 pmol) failed to increase thefiring rate of 5-HT neurons, in situ hybridization showed that the dopamine (DA) D-2 receptor transcript was almost absent in the DR and abundant in the substantia nigra (SN) and the periaqueductal grey matter (PAG). Using dual probe microdialysis, the application of tetrodotoxin or apomorphine in SN significantly increased the DR 5-HT output. Thus, the discrepancy between local and systemic effects of dopaminergic agonists and the absence of DAD, receptor transcript in 5-HT neurons suggest that DA D-2 receptors outside the DR control serotonergic activity.

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Documento generato il 11/07/20 alle ore 21:02:48