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Titolo:
Changes in regional energy metabolism after closed head injury in the rat
Autore:
Mautes, AEM; Thome, D; Steudel, WI; Nacimiento, AC; Yang, Y; Shohami, E;
Indirizzi:
Univ Saarland, Sch Med, Neurosurg Res Lab, Homburg, Germany Univ SaarlandHomburg Germany Med, Neurosurg Res Lab, Homburg, Germany Univ Saarland, Sch Med, Dept Neurosurg, Homburg, Germany Univ Saarland Homburg Germany Sch Med, Dept Neurosurg, Homburg, Germany Hebrew Univ Jerusalem, Dept Pharmacol, Sch Pharm, Jerusalem, Israel HebrewUniv Jerusalem Jerusalem Israel ol, Sch Pharm, Jerusalem, Israel
Titolo Testata:
JOURNAL OF MOLECULAR NEUROSCIENCE
fascicolo: 1, volume: 16, anno: 2001,
pagine: 33 - 39
SICI:
0895-8696(200102)16:1<33:CIREMA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRAUMATIC BRAIN INJURY; NECROSIS-FACTOR-ALPHA; AMYLOID PRECURSOR PROTEIN; TNF-ALPHA; IMPAIRED MITOCHONDRIAL; CYTOKINE PRODUCTION; GLUCOSE-UTILIZATION; EXPRESSION; INTERLEUKIN-6; DYSFUNCTION;
Keywords:
regional; ATP; glucose; lactate; closed head injury (CHI); rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Mautes, AEM Univ Saarland, Sch Med, Neurosurg Res Lab, Homburg, Germany Univ Saarland Homburg Germany urg Res Lab, Homburg, Germany
Citazione:
A.E.M. Mautes et al., "Changes in regional energy metabolism after closed head injury in the rat", J MOL NEURO, 16(1), 2001, pp. 33-39

Abstract

We examined in the present investigation regional ATP, glucose, and lactate content in the cortical and subcortical structures, in a rat model of closed head injury (CHI). In serial tissue sections bioluminescence imaging ofATP, glucose, and lactate was performed at 4 h, 12 h and 24 h (n 4/5 per time point with) after the induction of CHI or sham surgery. Bioluminescenceimages were analyzed by computer-assisted densitometry, at the lesion site, in remote cortical areas, and in the subcortical structures (thalamus andcaudate nucleus). ATP content was significantly decreased at the lesion site after 4 h and in the remote cortex at 12 h post-injury. At 12 h, the ATPcontent reached baseline levels on the ipsilateral side and at 24 h also at remote lateral parietal sites. In the contralateral cortex, ATP increasedtransiently above the baseline at 12 h. No significant changes in ATP werefound in the thalamus and caudate nucleus. Cortical glucose and lactate contents could not be discerned over time. Following CHI there is an acute and progressive, yet transient, ischemic cortical profile, which is not reflected in subcortical areas.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 06:26:16