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Titolo:
Colony-stimulating factors in stem cell transplantation: Effect on qualityof life
Autore:
Godder, KT; Henslee-Downey, PJ;
Indirizzi:
Palmetto Richland Mem Hosp, Div Transplantat Med, Columbia, SC USA Palmetto Richland Mem Hosp Columbia SC USA plantat Med, Columbia, SC USA Univ S Carolina, Columbia, SC 29208 USA Univ S Carolina Columbia SC USA 29208 S Carolina, Columbia, SC 29208 USA
Titolo Testata:
JOURNAL OF HEMATOTHERAPY & STEM CELL RESEARCH
fascicolo: 2, volume: 10, anno: 2001,
pagine: 215 - 228
SICI:
1525-8165(200104)10:2<215:CFISCT>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW TRANSPLANTATION; HIGH-DOSE CHEMOTHERAPY; PLACEBO-CONTROLLED TRIAL; HEMATOPOIETIC PROGENITOR CELLS; ASPERGILLUS-FUMIGATUS HYPHAE; ACUTE MYELOGENOUS LEUKEMIA; ACUTE MYELOID-LEUKEMIA; NON-HODGKINS-LYMPHOMA; PERIPHERAL-BLOOD; GM-CSF;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
92
Recensione:
Indirizzi per estratti:
Indirizzo: Godder, KT 425 E 86 St, New York, NY 10028 USA 425 E 86 St New York NY USA 10028 6 St, New York, NY 10028 USA
Citazione:
K.T. Godder e P.J. Henslee-Downey, "Colony-stimulating factors in stem cell transplantation: Effect on qualityof life", J HEMATH ST, 10(2), 2001, pp. 215-228

Abstract

Health-related quality of life (QOL) is poorest during the immediate post-transplantation period, but the impact of medical interventions during thisperiod has not been studied. Colony-stimulating factors (CSFs), which are used to minimize short-term negative outcomes, might be expected to improveQOL; however, little is published about their impact on QOL during this period. We conducted a MEDLINE search to identify studies reporting on outcomes of stem cell transplantation (SCT) affected by the CSFs, mainly sargramostim and filgrastim, End points studied were: mucositis, incidence and typeof infection, duration of hospitalization, time to myeloid engraftment, and quantity and quality of harvested cells, To impute the impact of CSFs on QOL post-SCT, we also reviewed the association between QOL and CSF outcomesin other circumstances. Data suggest that both CSFs improve QOL in the early autologous or allogeneic post-bone marrow transplantation period. Poor QOL caused by infection and increased length of hospital stay is expected tobe improved by sargramostim, Time to myeloid engraftment, when negatively affecting QOL, is expected to be improved with both CSFs; however, the timeto myeloid engraftment is consistently shorter with filgrastim, Current prospective trials designed to study the effects of CSFs in the immediate post-SCT period should collect QOL data.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:16:48