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Titolo:
Neutrophil respiratory burst activity and pro- and anti-inflammatory cytokines in AAA surgery: Conventional versus endoluminal treatment
Autore:
Parodi, JC; Ferreira, LM; Fornari, MC; Berardi, VE; Diez, RA;
Indirizzi:
Univ Buenos Aires, Fac Med, Segunda Catedra Farmacol, Lab Immunofarmacol, RA-1121 Buenos Aires, DF, Argentina Univ Buenos Aires Buenos Aires DF Argentina RA-1121 Aires, DF, Argentina Inst Cardiovasc Buenos Aires, Buenos Aires, DF, Argentina Inst Cardiovasc Buenos Aires Buenos Aires DF Argentina es, DF, Argentina
Titolo Testata:
JOURNAL OF ENDOVASCULAR THERAPY
fascicolo: 2, volume: 8, anno: 2001,
pagine: 114 - 124
SICI:
1526-6028(200104)8:2<114:NRBAAP>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
AORTIC-ANEURYSM REPAIR; ENDOVASCULAR TREATMENT; BIOLOGICAL RESPONSES; MONOCYTE ACTIVATION; RECEPTOR ANTAGONIST; SEPTIC SHOCK; INTERLEUKIN-6; ENDOTOXEMIA; EXPERIENCE; GENERATION;
Keywords:
endovascular grafting; surgical stress; vascular injury; HLA antigens;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Diez, RA Univ Buenos Aires, Fac Med, Segunda Catedra Farmacol, Lab Immunofarmacol, Paraguay 2155,Piso 16, RA-1121 Buenos Aires, DF, Argentina Univ Buenos Aires Paraguay 2155,Piso 16 Buenos Aires DF Argentina RA-1121
Citazione:
J.C. Parodi et al., "Neutrophil respiratory burst activity and pro- and anti-inflammatory cytokines in AAA surgery: Conventional versus endoluminal treatment", J ENDOVAS T, 8(2), 2001, pp. 114-124

Abstract

Purpose: To examine the inflammatory impact of endovascular and conventional surgery of abdominal aortic aneurysm (AAA) as assessed by the activationof neutrophils and serum levels of pro- and anti-inflammatory cytokines. Methods: Twenty-four patients undergoing AAA exclusion were treated with either endovascular (n = 14) or conventional (n=10) techniques. Clinical andhematological data, respiratory burst of neutrophils, and the expression of adhesion and activation molecules (CD18, CD11b, CD69, and HLA-DR) were analyzed by flow cytometry. The enzyme-linked immunosorbent assay technique was used to measure proinflammatory cytokine interleukin (IL)-8 and anti-inflammatory cytokines IL-l receptor antagonist (IL-1RA) and transforming growth factor beta1 (TGF-beta1). Results: All patients, most of whom had normal cytokine values before surgery, were successfully treated. No significant changes were found in surface antigens. Basal respiratory burst was quite heterogeneous; in all cases respiratory burst activity decreased after surgery and remained low throughout the observation period. Despite marked interpatient differences, IL-1RA and IL-8 increased after surgery, whereas TGF-beta1 decreased, although thevariation achieved statistical significance only in the conventional group. Elevated IL-1RA returned to normal within 48 hours in the endoluminal group, whereas the level remained high in the conventional group in the last sample. Conclusions: Despite heterogeneity before surgery, the respiratory burst decreased for most of the patients regardless of the approach, and both techniques increased IL-1RA. Although both procedures seemed to decrease TGF-beta1, the difference was significant only with the conventional approach. IL-1RA levels fell toward basal values quicker in the endograft patients, suggesting that the endoluminal approach was less aggressive.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 10:07:07