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Titolo:
Normal CK, elevated MB predicts complications in acute coronary syndromes
Autore:
Peacock, WF; Emerman, CL; McErlean, ES; DeLuca, SA; VanLente, F; Lowrie, M; Rao, JS; Nissen, SE;
Indirizzi:
Cleveland Clin Fdn, Dept Emergency Med, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 cy Med, Cleveland, OH 44195 USA Cleveland Clin Fdn, Dept Cardiol, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 ardiol, Cleveland, OH 44195 USA Cleveland Clin Fdn, Dept Clin Pathol, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 Pathol, Cleveland, OH 44195 USA Cleveland Clin Fdn, Dept Biostat, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 iostat, Cleveland, OH 44195 USA
Titolo Testata:
JOURNAL OF EMERGENCY MEDICINE
fascicolo: 4, volume: 20, anno: 2001,
pagine: 385 - 390
SICI:
0736-4679(200105)20:4<385:NCEMPC>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYOCARDIAL-INFARCTION; CREATINE-KINASE ACTIVITY; PRACTICE GUIDELINES COMMITTEE; ASSOCIATION TASK-FORCE; PROGNOSTIC-SIGNIFICANCE; ISOENZYME; INJURY; RECOMMENDATIONS; MANAGEMENT; MARKERS;
Keywords:
creatine kinase; chest pain; myocardial infarction; unstable angina; emergency medicine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Peacock, WF Cleveland Clin, Emergency Dept, 9500 Euclid Ave, Cleveland, OH44195 USA Cleveland Clin 9500 Euclid Ave Cleveland OH USA 44195 4195 USA
Citazione:
W.F. Peacock et al., "Normal CK, elevated MB predicts complications in acute coronary syndromes", J EMERG MED, 20(4), 2001, pp. 385-390

Abstract

The implications of an elevated Creatine kinase (CK)-MB isoenzyme (MB) in suspected acute coronary syndromes, with a normal total CR, is not well established. Despite many guidelines on managing patients with acute coronary ischemia, none indicates strategies for patients with elevated MB and with a normal CK, The outcome consequence of this result is not firmly established, Our objective was to prospectively evaluate outcomes in patients with suspected acute coronary syndromes, normal initial total CK, and increased RIB. All Emergency Department patients with suspected acute coronary syndromes and creatinine <2.0 mg/dL were eligible for study entry, Serial CK and hip fractions were measured on arrival in the Emergency Department, then 8 and 16 h postpresentation, A composite outcome of death, Q-wave myocardial infarction, or revascularization was defined at the index visit and 6 monthslater. Outcomes were determined by blinded record review and by telephone contact, In the 698 patients entered, the acute composite outcome rate was 25% (175) and 6.3% (44) at 6 months. Acute and 6 month adverse outcome rates were statistically the same for all patients with an elevated hip fraction, regardless of the total CK level, An elevated R-IB conferred a higher event rate than did a normal MB. We conclude that the adverse event rate for patients with suspected acute coronary syndromes and an elevated MB is the same whether or not the total CK is elevated, These patients should be considered as having had an acute coronary syndrome, (C) 2001 Elsevier Science Inc.

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Documento generato il 02/04/20 alle ore 00:05:57