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Titolo:
A new subdivision of anterior piriform cortex and associated deep nucleus with novel features of interest for olfaction and epilepsy
Autore:
Ekstrand, JJ; Domroese, ME; Johnson, DMG; Feig, SL; Knodel, SM; Behan, M; Haberly, LB;
Indirizzi:
Univ Wisconsin, Dept Anat, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 sin, Dept Anat, Madison, WI 53706 USA Univ Wisconsin, Neurosci Training Program, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 aining Program, Madison, WI 53706 USA Univ Wisconsin, MD PhD Program, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 MD PhD Program, Madison, WI 53706 USA Univ Wisconsin, Dept Comparat Biosci, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 omparat Biosci, Madison, WI 53706 USA
Titolo Testata:
JOURNAL OF COMPARATIVE NEUROLOGY
fascicolo: 3, volume: 434, anno: 2001,
pagine: 289 - 307
SICI:
0021-9967(20010604)434:3<289:ANSOAP>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMATE ORBITOFRONTAL CORTEX; MEDIAL PREFRONTAL CORTEX; CHANDELIER CELL AXONS; VENTROLATERAL ORBITAL CORTEX; COMMISSURAL FIBER SYSTEMS; GABA UPTAKE INHIBITOR; PREPIRIFORM CORTEX; EFFERENT CONNECTIONS; NEURONAL RESPONSES; PREPYRIFORM CORTEX;
Keywords:
olfactory cortex; orbitofrontal cortex; prefrontal cortex; limbic system; epilepsy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
96
Recensione:
Indirizzi per estratti:
Indirizzo: Haberly, LB Univ Wisconsin, Dept Anat, 1300 Univ Ave, Madison, WI 53706 USA Univ Wisconsin 1300 Univ Ave Madison WI USA 53706 WI 53706 USA
Citazione:
J.J. Ekstrand et al., "A new subdivision of anterior piriform cortex and associated deep nucleus with novel features of interest for olfaction and epilepsy", J COMP NEUR, 434(3), 2001, pp. 289-307

Abstract

The anterior part of the piriform cortex (the APC) has been the focus of cortical-level studies of olfactory coding and associative processes and hasattracted considerable attention as a result of a unique capacity to initiate generalized tonic-clonic seizures. Based on analysis of cytoarchitecture, connections, and immunocytochemical markers, a new subdivision of the APC and an associated deep nucleus are distinguished in the rat. As a result of its ventrorostral location in the APC, the new subdivision is termed theAPC(VR). The deep nucleus is termed the pre-endopiriform nucleus (pEn) based on location and certain parallels to the endopiriform nucleus. The APC, has unique features of interest for normal function: immunostaining suggests that it receives input fi om tufted cells in the olfactory bulb in addition to mitral cells, and it provides a heavy, rather selective projection from the piriform cortex to the ventrolateral orbital cortex (VLO), a prefrontal area where chemosensory, visual, and spatial information converges. TheAPC, also has di- and tri-synaptic projections to the VLO via the pEn and the submedial thalamic nucleus. The pEn is of particular interest from a pathological standpoint because it corresponds in location to the physiologically defined "deep piriform cortex" ("area tempestas") from which convulsants initiate temporal lobe seizures, and blockade reduces ischemic damage tothe hippocampus. Immunostaining revealed novel features of the pEn and APC(VR) that could alter excitability, including a near-absence of gamma -aminobutyric acid (GABA)ergic "cartridge'' endings on axon initial segments, few cholecystokinin (CCK)-positive basket cells, and very low gamma -aminobutyric acid transporter-1 (GAT1)-like immunoreactivity. Normal functions of the APC(VR)-pEn may require a shaping of neuronal activity by inhibitory processes in a fashion that renders this region susceptible to pathological behavior. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 13:08:24