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Titolo:
Autoregulation of neurotransmitter release at autonomic nerve terminals: aquestionable theory
Autore:
Kalsner, S;
Indirizzi:
CUNY, Sch Med, Sophie Davis Sch Biomed Educ, Dept Physiol & Pharmacol, NewYork, NY 10031 USA CUNY New York NY USA 10031 ept Physiol & Pharmacol, NewYork, NY 10031 USA
Titolo Testata:
JOURNAL OF AUTONOMIC PHARMACOLOGY
fascicolo: 5-6, volume: 20, anno: 2000,
pagine: 271 - 279
SICI:
0144-1795(200010/12)20:5-6<271:AONRAA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-ADRENOCEPTOR ANTAGONISTS; RABBIT PULMONARY-ARTERY; NEUROMUSCULAR-TRANSMISSION; H-3-NORADRENALINE RELEASE; ADRENERGIC TRANSMISSION; NORADRENALINE RELEASE; STIMULATION; MODULATION; FEEDBACK; AUTORECEPTORS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Kalsner, S CUNY, Sch Med, Sophie Davis Sch Biomed Educ, Dept Physiol & Pharmacol, 138th St & Convent Ave, New York, NY 10031 USA CUNY 138th St & Convent Ave New York NY USA 10031 NY 10031 USA
Citazione:
S. Kalsner, "Autoregulation of neurotransmitter release at autonomic nerve terminals: aquestionable theory", J AUT PHARM, 20(5-6), 2000, pp. 271-279

Abstract

1 The evidence for feedback regulation of neurotransmitter release by means of autoreceptors is questioned.2 Autoreceptor function must meet the expectations for feedback loops. However, this concordance has not been observed in most neuroeffector systems.3 The characteristics of per pulse transmitter release with changes in theparameters of stimulation in several autonomic systems do not support the ongoing operation of negative feedback loop mediated by locally released transmitter. Also, the effects of antagonists and agonists often do not comply with feedback expectations.4 Evidence is provided that agonists and antagonists act at different locito achieve their inhibiting and potentiating effects on transmitter release.5 Future efforts should be directed to exploring the mechanism(s) of antagonist action and to a system-by-system analysis of the evidence for and against autoreceptor operation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 09:11:56