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Titolo:
Managing influenza: Amantadine, rimantadine and beyond
Autore:
Fleming, DM;
Indirizzi:
Northfield Hlth Ctr, Birmingham B31 1QT, W Midlands, England Northfield Hlth Ctr Birmingham W Midlands England B31 1QT dlands, England
Titolo Testata:
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
fascicolo: 3, volume: 55, anno: 2001,
pagine: 189 - 195
SICI:
1368-5031(200104)55:3<189:MIARAB>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
RANDOMIZED CONTROLLED TRIAL; NEURAMINIDASE INHIBITOR OSELTAMIVIR; A VIRUS; CLINICAL EFFICACY; HEALTHY-ADULTS; DOUBLE-BLIND; INFECTION; ZANAMIVIR; SAFETY; PROPHYLAXIS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Fleming, DM Northfield Hlth Ctr, Birmingham B31 1QT, W Midlands, England Northfield Hlth Ctr Birmingham W Midlands England B31 1QT and
Citazione:
D.M. Fleming, "Managing influenza: Amantadine, rimantadine and beyond", INT J CL PR, 55(3), 2001, pp. 189-195

Abstract

Amantadine and rimantadine are effective in the treatment and prophylaxis of influenza A. Neither drug, however, has achieved widespread acceptance because of the rapid development of viral resistance, their lack of activityagainst influenza B and, in the case of amantadine, adverse events. Complete cross-resistance occurs with these compounds and is associated with a single nucleotide change in the Mp protein. Resistant variants are transmissible and fully pathogenic. Zanamivir is the first widely approved neuraminidase inhibitor for the treatment of influenza. It is delivered directly to the primary site of viral replication, the respiratory tract, and is well tolerated and effective in the treatment of both influenza A and B. Data in prophylaxis are also encouraging. During the extensive clinical programme noevidence for the emergence of drug-resistant strains with acute therapy was found. Zanamivir represents a significant advance over older agents in the management of influenza A and B.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 07:37:50