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Titolo:
Phosphodiesterase 5 inhibition: Effects on the coronary vasculature
Autore:
Jackson, G;
Indirizzi:
St Thomas Hosp, Dept Cardiac, London SE1 7EH, England St Thomas Hosp London England SE1 7EH t Cardiac, London SE1 7EH, England
Titolo Testata:
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
fascicolo: 3, volume: 55, anno: 2001,
pagine: 183 - 188
SICI:
1368-5031(200104)55:3<183:P5IEOT>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
SILDENAFIL CITRATE VIAGRA; ERECTILE DYSFUNCTION; ORAL SILDENAFIL; ARTERY DISEASE; NITRIC-OXIDE; SAFETY; HEMODYNAMICS; EFFICACY; STENOSIS; FLOW;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Jackson, G St Thomas Hosp, Dept Cardiac, London SE1 7EH, England St ThomasHosp London England SE1 7EH London SE1 7EH, England
Citazione:
G. Jackson, "Phosphodiesterase 5 inhibition: Effects on the coronary vasculature", INT J CL PR, 55(3), 2001, pp. 183-188

Abstract

As a potent and selective inhibitor of cyclic guanosine monophosphate-specific phosphodiesterase 5 (PDE5), sildenafil citrate (Viagra (R)) is safe and effective in men with erectile dysfunction (ED) of diverse aetiologies, including patients with common cardiovascular diseases who are not receivingorganic nitrates or nitrate donor drugs. In retrospective analyses of extensive clinical trials, siidenafil treatment for ED was not associated with any increase in cardiac risk. In haemodynamic studies, sildenafil produced small decreases in systemic and pulmonary blood pressure but caused no adverse cardiovascular effects in specific populations of men with coronary heart disease. Sildenafil also caused no significant changes in coronary bloodflow but had a positive effect on coronary flow reserve in men with severecoronary artery disease. Together with findings from other studies, these data suggest that PDES may play an important role in the regulation of coronary blood flow in the healthy and diseased heart.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:31:38