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Titolo:
A meta-analysis of the efficacy and tolerability of paroxetine versus tricyclic antidepressants in the treatment of major depression
Autore:
Montgomery, SA;
Indirizzi:
Univ London Imperial Coll Sci Technol & Med, Sch Med, London, England UnivLondon Imperial Coll Sci Technol & Med London England don, England
Titolo Testata:
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
fascicolo: 3, volume: 16, anno: 2001,
pagine: 169 - 178
SICI:
0268-1315(200105)16:3<169:AMOTEA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN REUPTAKE INHIBITORS; NATIONAL-COMORBIDITY-SURVEY; DOUBLE-BLIND MULTICENTER; EUROPEAN-SOCIETY II; PANIC DISORDER; PRIMARY-CARE; COMPARING PAROXETINE; ANXIETY DISORDERS; DISCONTINUATION RATES; MENTAL-DISORDERS;
Keywords:
anxiety; clomipramine; major depression; meta-analysis; paroxetine; tricyclic antidepressant;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Montgomery, SA POB 8751, London W13 8WH, England POB 8751 London EnglandW13 8WH , London W13 8WH, England
Citazione:
S.A. Montgomery, "A meta-analysis of the efficacy and tolerability of paroxetine versus tricyclic antidepressants in the treatment of major depression", INT CLIN PS, 16(3), 2001, pp. 169-178

Abstract

This meta-analysis examined efficacy and tolerability data from 39 randomized, double-blind, parallel-group studies comparing paroxetine (n = 1924) with clomipramine (n = 141) or other tricyclic antidepressants (TCAs; n = 1693) in the treatment of major depression. Paroxetine had comparable antidepressant efficacy to TCAs, including clomipramine, as assessed by response rates based on a less than or equal to 50% reduction in Hamilton Rating Scale for Depression (HAMD) total score (58-66%) and a HAMD total score less than or equal to 8 (38-48%) at endpoint, and absolute improvements in HAMD total score (mean change 12.3-14.5), Absolute improvements in HAMD anxiety factor scores were similar between paroxetine and clomipramine (mean change 2.3 versus 2.4, P = 0.566), but paroxetine was statistically significantly more effective on this measure than other TCAs (mean change 2.3 versus 2.1, P = 0.028). The proportion of patients who experienced adverse events with > 1% incidence was statistically significantly lower with paroxetine than with clomipramine (64% versus 77%, P = 0.02) or other TCAs (64% versus 71%, P < 0.001). The incidence of patient withdrawals due to adverse events was also statistically significantly lower with paroxetine than with clomipramine (17% versus 27%, P = 0.014), but an advantage seen for paroxetine over other TCAs (17% versus 20%, P = 0.130) did not reach statistical significance, These findings demonstrate that paroxetine has comparable efficacy to and better tolerability than TCAs, including clomipramine, and is therefore an appropriate treatment strategy for depression, particularly in the commonclinical situation where concomitant anxiety symptoms are present. Int clin Psychopharmacol 16:169-178 (C) 2001 Lippincott Williams & Wilkins.

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Documento generato il 22/01/20 alle ore 12:57:41