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Titolo:
The incidence of lymphoid and myeloid malignancies among hospitalized Crohn's disease patients
Autore:
Arseneau, KO; Stukenborg, GJ; Connors, AF; Cominelli, F;
Indirizzi:
Univ Virginia, Hlth Syst, Digest Hlth Ctr, Charlottesville, VA USA Univ Virginia Charlottesville VA USA t Hlth Ctr, Charlottesville, VA USA Univ Virginia, Hlth Syst, Dept Hlth Evaluat Sci, Charlottesville, VA USA Univ Virginia Charlottesville VA USA valuat Sci, Charlottesville, VA USA
Titolo Testata:
INFLAMMATORY BOWEL DISEASES
fascicolo: 2, volume: 7, anno: 2001,
pagine: 106 - 112
SICI:
1078-0998(200105)7:2<106:TIOLAM>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFLAMMATORY BOWEL-DISEASE; IMMUNOSUPPRESSIVE THERAPY; RHEUMATOID-ARTHRITIS; MORTALITY;
Keywords:
Crohn's disease; lymphoma; leukemia; myeloma; incidence; administrative data;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Cominelli, F UVA Hlth Syst, Div Gastroenterol & Hepatol, Box 10013, Charlottesville, VA22906 USA UVA Hlth Syst Box 10013 Charlottesville VA USA 229062906 USA
Citazione:
K.O. Arseneau et al., "The incidence of lymphoid and myeloid malignancies among hospitalized Crohn's disease patients", INFLAMM B D, 7(2), 2001, pp. 106-112

Abstract

An association may exist between Crohn's disease (CD) and lymphoid/myeloidmalignancies. We aimed to evaluate the 2-year cumulative incidence rate oflymphoid/myeloid malignancy among hospitalized CD patients. This is a retrospective cohort study using hospital discharge data from California and Virginia. Cohorts were defined by the presence or absence of a CD diagnosis in all patients discharged during a single calendar year (Year-2). The presence or absence of lymphoid/myeloid malignancy was determined for all hospitalizations during a l-year period (Year-l to Year-4) for each member of both cohorts. To obtain a 2-year cumulative incidence rate, patients with lymphoid/myeloid malignancy prior to or at the time of their first admission inYear-2 were excluded. Patients were followed for 8 quarters after this admission for the incidence of lymphoid/myeloid malignancy. Cumulative incidence rates and odds ratios were calculated. The crude 2-year incidence rate of lymphoid/myeloid malignancy among hospitalized CD patients was 3.87/1.000CD patients (21/5,426; 95% CI = 2.40-5.92). The odds ratio adjusted for age, gender, and race was 2.04 (95% CI = 1.33-3.14, p < 0.001). The 2-year cumulative incidence of lymphoid/myeloid malignancies among hospitalized CD patients is greater than that seen in hospitalized patients without CD. Thisfinding supports the need for further prospective population-based studies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 21:49:31