Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Strain-dependent susceptibility to MPTP and MPP+-induced parkinsonism is determined by glia
Autore:
Smeyne, M; Goloubeva, O; Smeyne, RJ;
Indirizzi:
St Jude Childrens Res Hosp, Dept Dev Neurobiol, Memphis, TN 38015 USA St Jude Childrens Res Hosp Memphis TN USA 38015 ol, Memphis, TN 38015 USA St Jude Childrens Res Hosp, Dept Biostat & Epidemiol, Memphis, TN 38015 USA St Jude Childrens Res Hosp Memphis TN USA 38015 ol, Memphis, TN 38015 USA
Titolo Testata:
GLIA
fascicolo: 2, volume: 34, anno: 2001,
pagine: 73 - 80
SICI:
0894-1491(20010415)34:2<73:SSTMAM>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESENCEPHALIC DOPAMINERGIC-NEURONS; NITRIC-OXIDE SYNTHASE; IN-VIVO; 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE MPTP; OXIDATIVE STRESS; NEUROTOXIN MPTP; SUBSTANTIA-NIGRA; TRANSPORTER GENE; MOUSE-BRAIN; DISEASE;
Keywords:
Parkinson's disease; reactive oxygen species; dopamine; cell culture;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: Smeyne, RJ St Jude Childrens Res Hosp, Dept Dev Neurobiol, 332 N Lauderdale, Memphis,TN 38015 USA St Jude Childrens Res Hosp 332 N Lauderdale MemphisTN USA 38015
Citazione:
M. Smeyne et al., "Strain-dependent susceptibility to MPTP and MPP+-induced parkinsonism is determined by glia", GLIA, 34(2), 2001, pp. 73-80

Abstract

Parkinson's disease (PD) is a debilitating neurological disorder that strikes approximately 2% of people over age 50. Current hypotheses propose thatthe cause of PD is multifactorial, involving environmental agents and genetic predisposition. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induces parkinsonism in many species, including humans and shows strain specificity in mice. The mechanism of strain specificity, however, remains unknown. Using novel chimeric murine substantia nigra cultures, we demonstrate that sensitivity to MPTP is conferred by glia and that it does not involve the MAO-B conversion of MPTP to MPP+. C57Bl/6J dopaminergic neurons exposed to MPP+ demonstrated a 39% loss when cultured on C57Bl/6J glia compared with17% neuron loss when cultured on resistant SWR/J glia. Similarly, SWR/J neurons exposed to MPP+ demonstrated a 4% loss when cultured on SWR/J glia, but a 14% loss when cultured on sensitive C57Bl/6J glia. The identification of glia as the critical cell type in the genesis of experimental Parkinsonism provides a target for the development of new anti-parkinsonian therapies. GLIA 34:73-80, 2001. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:27:58