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Titolo:
Genomic anatomy of a premier major histocompatibility complex paralogous region on chromosome 1q21-q22
Autore:
Shiina, T; Ando, A; Suto, Y; Kasai, F; Shigenari, A; Takishima, N; Kikkawa, E; Iwata, K; Kuwano, Y; Kitamura, Y; Matsuzawa, Y; Sano, K; Nogami, M; Kawata, H; Li, SY; Fukuzumi, Y; Yamazaki, M; Tashiro, H; Tamiya, G; Kohda, A; Okumura, K; Ikemura, T; Soeda, E; Mizuki, N; Kimura, M; Bahram, S; Inoko, H;
Indirizzi:
Tokai Univ, Sch Med, Div Mol Life Sci, Dept Genet Informat, Isehara, Kanagawa 2591193, Japan Tokai Univ Isehara Kanagawa Japan 2591193 sehara, Kanagawa 2591193, Japan Univ Tokyo, Grad Sch Sci, Dept Biol Sci, Bunkyo Ku, Tokyo 1130033, Japan Univ Tokyo Tokyo Japan 1130033 Biol Sci, Bunkyo Ku, Tokyo 1130033, Japan Fujiya Co Ltd, Biosci Res Lab, Hadano, Kanagawa 2570031, Japan Fujiya Co Ltd Hadano Kanagawa Japan 2570031 dano, Kanagawa 2570031, Japan Natl Inst Genet, Dept Evolut Genet, Mishima, Shizuoka 4110801, Japan Natl Inst Genet Mishima Shizuoka Japan 4110801 a, Shizuoka 4110801, Japan RIKEN, Life Sci Ctr, Tsukuba, Ibaraki 3050861, Japan RIKEN Tsukuba Ibaraki Japan 3050861 Ctr, Tsukuba, Ibaraki 3050861, Japan Yokohama City Univ, Sch Med, Dept Ophthalmol, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan Yokohama City Univ Yokohama Kanagawa Japan 2360004 anagawa 2360004, Japan Ctr Rech Immunol & Hematol, INSERM, CReS, F-67085 Strasbourg, France Ctr Rech Immunol & Hematol Strasbourg France F-67085 Strasbourg, France
Titolo Testata:
GENOME RESEARCH
fascicolo: 5, volume: 11, anno: 2001,
pagine: 789 - 802
SICI:
1088-9051(200105)11:5<789:GAOAPM>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLASS-I REGION; T-CELL RECOGNITION; ERYTHROCYTE ALPHA-SPECTRIN; RECEPTOR GENE FAMILY; INSITU HYBRIDIZATION; SEQUENCE-ANALYSIS; ANTIGEN GENES; DNA-SEQUENCE; CD1 GENES; NUCLEOTIDE-SEQUENCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
83
Recensione:
Indirizzi per estratti:
Indirizzo: Inoko, H Tokai Univ, Sch Med, Div Mol Life Sci, Dept Genet Informat, Isehara, Kanagawa 2591193, Japan Tokai Univ Isehara Kanagawa Japan 2591193 anagawa 2591193, Japan
Citazione:
T. Shiina et al., "Genomic anatomy of a premier major histocompatibility complex paralogous region on chromosome 1q21-q22", GENOME RES, 11(5), 2001, pp. 789-802

Abstract

Human chromosomes 1q21-q25, 6p21.3-22.2, 9q33-q34, and 19p13.1-p13.4 carryclusters of paralogous loci, to date best defined by the flagship 6p MHC region. They have presumably been created by two rounds of large-scale genomic duplications around the time of vertebrate emergence. Phylogenetically, the 1q21-25 region seems most closely related to the 6p21.3 MHC region, as it is only the MHC paralogous region that includes bona fide MHC class I genes, the CD1 and MR1 loci. Here, to clarify the genomic structure of this model MHC paralogous region as well as to gain insight into the evolutionarydynamics of the entire quadriplication process, a detailed analysis of a critical 1.7 megabase (Mb) region was performed. To this end, a composite, deep, YAC, BAG, and PAC contig encompassing all five CD1 genes and linking the centromeric +P5 locus to the telomeric KRTC7 locus was constructed. Within this contig a 1.1-Mb BAC and PAC core segment joining CD1D to FCER1A wasfully sequenced and thoroughly analyzed. This led to the mapping of a total of 41 genes (12 expressed genes, 12 possibly expressed genes, and 17 pseudogenes), among which 31 were novel. The latter include 20 olfactory receptor (OR) genes, 9 of which are potentially expressed. Importantly, CD1, SPTA1, OR, and FCER1A belong to multigene families, which have paralogues in the other three regions. Furthermore, it is noteworthy that 12 of the 13 expressed genes in the 1q21-q22 region around the CD1 loci are immunologically relevant. In addition to CD1A-E, these include SPTA1, MNDA, IFI-16, AIM2, BL1A, FY and FCER1A. This functional convergence of structurally unrelated genes is reminiscent of the 6p MHC region, and perhaps represents the emergence of yet another antigen presentation gene cluster, in this case dedicated to lipid/glycolipid antigens rather than antigen-derived peptides.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 16:43:13