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Titolo:
Identification and characterization of the potential promoter regions of 1031 kinds of human genes
Autore:
Suzuki, Y; Tsunoda, T; Sese, J; Taira, H; Mizushima-Sugano, J; Hata, H; Ota, T; Isogai, T; Tanaka, T; Nakamura, Y; Suyama, A; Sakaki, Y; Morishita, S; Okubo, K; Sugano, S;
Indirizzi:
Univ Tokyo, Inst Med Sci, Dept Virol, Minato Ku, Tokyo 1088639, Japan UnivTokyo Tokyo Japan 1088639 pt Virol, Minato Ku, Tokyo 1088639, Japan Univ Tokyo, Inst Med Sci, Ctr Human Genome, Minato Ku, Tokyo 1088639, Japan Univ Tokyo Tokyo Japan 1088639 n Genome, Minato Ku, Tokyo 1088639, Japan RIKEN, Inst Phys & Chem Res, Genom Sci Ctr, Wako, Saitama 3510106, Japan RIKEN Wako Saitama Japan 3510106 om Sci Ctr, Wako, Saitama 3510106, Japan Univ Tokyo, Grad Sch Frontier Sci, Dept Complex Sci & Engn, Bunkyo Ku, Tokyo 1130033, Japan Univ Tokyo Tokyo Japan 1130033 i & Engn, Bunkyo Ku, Tokyo 1130033, Japan Nippon Telegraph & Tel Publ Corp, Commun Sci Labs, Intelligent Commun Lab,Seiko, Kyoto 6190237, Japan Nippon Telegraph & Tel Publ Corp Seiko Kyoto Japan 6190237 6190237, Japan Helix Res Inst, Chiba 2920812, Japan Helix Res Inst Chiba Japan 2920812Helix Res Inst, Chiba 2920812, Japan Univ Tokyo, Dept Life Sci, Meguro Ku, Tokyo 1530041, Japan Univ Tokyo Tokyo Japan 1530041 Life Sci, Meguro Ku, Tokyo 1530041, Japan Osaka Univ, Inst Mol & Cell Biol, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 ll Biol, Suita, Osaka 5650871, Japan
Titolo Testata:
GENOME RESEARCH
fascicolo: 5, volume: 11, anno: 2001,
pagine: 677 - 684
SICI:
1088-9051(200105)11:5<677:IACOTP>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARCINOEMBRYONIC ANTIGEN GENE; RNA-POLYMERASE-II; TRANSCRIPTIONAL CONTROL; CPG ISLANDS; MESSENGER-RNAS; ELEMENTS; DNA; EXPRESSION; ALIGNMENT; SEQUENCES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Suzuki, Y Univ Tokyo, Inst Med Sci, Dept Virol, Minato Ku, Tokyo 1088639, Japan Univ Tokyo Tokyo Japan 1088639 Minato Ku, Tokyo 1088639, Japan
Citazione:
Y. Suzuki et al., "Identification and characterization of the potential promoter regions of 1031 kinds of human genes", GENOME RES, 11(5), 2001, pp. 677-684

Abstract

To understand the mechanism of transcriptional regulation, it is essentialto identify and characterize the promoter, which is located proximal to the mRNA start site. To identify the promoters from the large volumes of genomic sequences, we used mRNA start sites determined by a large-scale sequencing of the cDNA libraries constructed by the "oligo-capping" method. We aligned the mRNA start sites with the genomic sequences and retrieved adjacentsequences as potential promoter regions (PPRs) for 1031 genes. The PPR sequences were searched to determine the frequencies of major promoter elements. Among 1031 PPRs, 329 (32%) contained TATA boxes, 872 (85%) contained initiators, 999 (97%) contained CC box, and 663 (64%) contained CAAT box. Furthermore, 493 (48%) PPRs were located in CpG islands. This frequency of CpG islands was reduced in TATA(+)/lnr(+) PPRs and in the PPRs of ubiquitously expressed genes. In the PPRs of the CGM2 gene, the DRA gene, and the TM30plgenes, which showed highly colon specific expression patterns, the consensus sequences of E boxes were commonly observed. The PPRs were also useful For exploring promoter SNPs.

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Documento generato il 07/07/20 alle ore 12:24:47