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Titolo:
Effects of Dmo1 on obesity, dyslipidaemia and hyperglycaemia in the OtsukaLong Evans Tokushima Fatty strain
Autore:
Okuno, S; Watanabe, TK; Ono, T; Oga, K; Mizoguchi-Miyakita, A; Yamasaki, Y; Goto, Y; Shinomiya, H; Momota, H; Miyao, H; Hayashi, I; Asai, T; Suzuki, M; Harada, Y; Hishigaki, H; Wakitani, S; Takagi, T; Nakamura, Y; Tanigami, A;
Indirizzi:
Otsuka Pharmaceut Co Ltd, Otsuka GEN Res Inst, Kawauchi, Tokushima 7710192, Japan Otsuka Pharmaceut Co Ltd Kawauchi Tokushima Japan 7710192 7710192, Japan Osaka Minami Natl Hosp, Dept Orthopaed Surg, Osaka 5868521, Japan Osaka Minami Natl Hosp Osaka Japan 5868521 ed Surg, Osaka 5868521, Japan Univ Tokyo, Inst Med Sci, Ctr Human Genome, Lab Genome Database,Minato Ku,Tokyo 1088639, Japan Univ Tokyo Tokyo Japan 1088639 e Database,Minato Ku,Tokyo 1088639, Japan Univ Tokyo, Inst Med Sci, Ctr Human Genome, Lab Mol Med,Minato Ku, Tokyo 1088639, Japan Univ Tokyo Tokyo Japan 1088639 b Mol Med,Minato Ku, Tokyo 1088639, Japan
Titolo Testata:
GENETICAL RESEARCH
fascicolo: 2, volume: 77, anno: 2001,
pagine: 183 - 190
SICI:
0016-6723(200104)77:2<183:EODOOD>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT DIABETES-MELLITUS; QUANTITATIVE TRAIT LOCI; BN X OLETF; GENETIC DISSECTION; SPONTANEOUS NIDDM; BACKCROSS RATS; GK RAT; MODEL; HYPERTRIGLYCERIDEMIA; MAP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Watanabe, TK Otsuka Pharmaceut Co Ltd, Otsuka GEN Res Inst, 463-10 Kagasuno, Kawauchi, Tokushima 7710192, Japan Otsuka Pharmaceut Co Ltd 463-10 Kagasuno Kawauchi Tokushima Japan 7710192
Citazione:
S. Okuno et al., "Effects of Dmo1 on obesity, dyslipidaemia and hyperglycaemia in the OtsukaLong Evans Tokushima Fatty strain", GENET RES, 77(2), 2001, pp. 183-190

Abstract

Whole-genome scans have identified Dmo1 as a major quantitative trait locus (QTL) for obesity and dyslipidaemia in the Otsuka Long Evans Tokushima Fatty (OLETF) rat. We have produced congenic rats for the Dmo1 locus, using marker-assisted speed congenic protocols, enforced by selective removal of other QTL regions (QTL-marker-assisted counterselection), to efficiently transfer chromosomal segments from non-diabetic Fischer 344 (F344) rats into the OLETF background. In the third generation of congenic animals, we observed a substantial therapeutic effect of the Dmo1 locus on lipid metabolism, obesity control and plasma glucose homeostasis. We conclude that single-allele correction of an impaired genetic pathway can generate a substantial therapeutic effect, despite the complex polygenic nature of type II diabetic syndromes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:41:36