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Titolo:
Concurrent expression of recombination activating genes 1 and 2 in zebrafish olfactory sensory neurons
Autore:
Jessen, JR; Jessen, TN; Vogel, SS; Lin, S;
Indirizzi:
Med Coll Georgia, Inst Mol Med & Genet, Augusta, GA 30912 USA Med Coll Georgia Augusta GA USA 30912 Med & Genet, Augusta, GA 30912 USA
Titolo Testata:
GENESIS
fascicolo: 4, volume: 29, anno: 2001,
pagine: 156 - 162
SICI:
1526-954X(200104)29:4<156:CEORAG>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
ODORANT RECEPTOR EXPRESSION; V(D)J RECOMBINATION; MULTIGENE FAMILY; EPITHELIUM; SYSTEM; RAG-1; TRANSGENESIS; PROTEINS; MICE;
Keywords:
RAG1and RAG2; zebrafish; olfaction; transgenesis; recombination;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Lin, S Med Coll Georgia, Inst Mol Med & Genet, 1120 15th St, Augusta, GA 30912 USA Med Coll Georgia 1120 15th St Augusta GA USA 30912 ta, GA 30912 USA
Citazione:
J.R. Jessen et al., "Concurrent expression of recombination activating genes 1 and 2 in zebrafish olfactory sensory neurons", GENESIS, 29(4), 2001, pp. 156-162

Abstract

Each olfactory sensory neuron (OSN) expresses a single odorant receptor (OR) from a large repertoire of clustered OR genes. It has been hypothesized that OR gene regulation may involve stochastic DNA rearrangement, which in lymphocytes requires the recombination activating genes, rag1 and rag2, We have recently demonstrated that rag1 is expressed in zebrafish OSNs, Here we report that rag2, the obligate partner for rag1 function, is also expressed in OSNs and that its expression pattern mimics that of rag1. The onset of rag1 and rag2 expression preceded that of known zebrafish ORs and the number of rag1-positive OSNs corresponded with the number expressing the olfactory cyclic nucleotide-gated cation channel, an OSN marker, Zebrafish OSNs are the first example of concurrent rag expression in a nonlymphoid tissue. The expression of rag1 and rag2 in OSNs adds to the list of similarities between the olfactory and immune systems that includes monoallelic and mutually exclusive gene expression. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 02:50:59