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Titolo:
Biotransformation and disposition of testosterone in the eastern mud snailIlyanassa obsoleta
Autore:
Gooding, MP; LeBlanc, GA;
Indirizzi:
N Carolina State Univ, Dept Environm & Mol Toxicol, Raleigh, NC 27695 USA N Carolina State Univ Raleigh NC USA 27695 Toxicol, Raleigh, NC 27695 USA
Titolo Testata:
GENERAL AND COMPARATIVE ENDOCRINOLOGY
fascicolo: 2, volume: 122, anno: 2001,
pagine: 172 - 180
SICI:
0016-6480(200105)122:2<172:BADOTI>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
FATTY-ACID ESTERS; NUCELLA-LAPILLUS; INDUCED IMPOSEX; DOG-WHELK; TRIBUTYLTIN; METABOLISM; IDENTIFICATION; NEOGASTROPODS; CONTAMINATION; INDICATOR;
Keywords:
Ilyanassa obsoleta; mud snail; fatty acid conjugates; testosterone; imposex; invertebrate endocrinology; tributyltin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Gooding, MP N Carolina State Univ, Dept Environm & Mol Toxicol, Box 7633, Raleigh, NC 27695 USA N Carolina State Univ Box 7633 Raleigh NC USA 27695 27695 USA
Citazione:
M.P. Gooding e G.A. LeBlanc, "Biotransformation and disposition of testosterone in the eastern mud snailIlyanassa obsoleta", GEN C ENDOC, 122(2), 2001, pp. 172-180

Abstract

Elevated testosterone levels have been reported to be associated with imposer (pseudohermaphroditism), the superimposition of male characteristics such as a penis and vas deferens on female gonachoristic snails. Tributyltin (TBT), a marine biocide in anti-fouling paints, is a known causal agent of imposer. Evidence suggests that imposer is elicited by TBT-mediated changesin the biotransformation and disposition of testosterone. To identify potential targets of TBT in gastropod species susceptible to imposer, biotransformation and disposition of testosterone in normal individuals must first be characterized. Nonimposex mud snail, Ilyanassa obsoleta, readily extracted [C-14] testosterone, added to aqueous media, and converted the testosterone to at least five apolar conjugates designated AP1 through APS. All were retained by the organisms. No significant amount of [C-14]testosterone was retained or eliminated as polar metabolites. Following enzymatic hydrolysisof the most abundant metabolite (AP1), free fatty acids and [C-14] testosterone were liberated. Furthermore, AP1 was produced when homogenized snail tissue was incubated with [C-14]testosterone and oleoyl coenzyme A or palmitoyl coenzyme A. These results indicate that AP1, which represents over 70%of the testosterone biotransformation products, is a fatty acid ester of testosterone. Apolar metabolites AP2-AP5 might represent testosterone derivatives that are multiply conjugated to fatty acid molecules. Fatty acid conjugates of testosterone have not been previously described in the gastropods. The esterification of testosterone to fatty acids might be a mechanism where by steroid titers are regulated and could represent a target of TBT toxicity. (C) 2001 Academic Press.

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Documento generato il 07/07/20 alle ore 06:18:10