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Titolo:
Therapeutic potential of Na-H exchange inhibitors for the treatment of heart failure
Autore:
Karmazyn, M;
Indirizzi:
Univ Western Ontario, Dept Pharmacol & Toxicol, London, ON N6A 5C1, CanadaUniv Western Ontario London ON Canada N6A 5C1 London, ON N6A 5C1, Canada
Titolo Testata:
EXPERT OPINION ON INVESTIGATIONAL DRUGS
fascicolo: 5, volume: 10, anno: 2001,
pagine: 835 - 843
SICI:
1354-3784(200105)10:5<835:TPONEI>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
NA+/H+ EXCHANGER; ANGIOTENSIN-II; HYPERTROPHY; RAT; SODIUM; MUSCLE; AMILORIDE; PROLIFERATION; STRETCH; MYOCARDIUM;
Keywords:
cariporide; hypertrophy; myocardial remodelling; NHE-1;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Karmazyn, M Univ Western Ontario, Dept Pharmacol & Toxicol, Med Sci Bldg, London, ON N6A 5C1, Canada Univ Western Ontario Med Sci Bldg London ON Canada N6A 5C1 ada
Citazione:
M. Karmazyn, "Therapeutic potential of Na-H exchange inhibitors for the treatment of heart failure", EXPERT OP I, 10(5), 2001, pp. 835-843

Abstract

The Na-H exchanger (NHE) represents a family of transporters which regulate intracellular pH by removing protons in exchange for sodium influx in an electroneutral 1:1 stoichiometric relationship. Six isoforms have thus Dr been identified with the NHE-1 subtype representing the primary isoform in the cardiac cell. It is well-established that NHE-1 contributes to cardiac injury produced by ischaemia and reperfusion and inhibitors of the antiporter exert excellent cardioprotection. More recent evidence suggests that NHE-1 may also be important for cell growth and may contribute to the maladaptive remodelling which contributes to heart failure particularly the early hypertrophic responses. Evidence from in vitro studies suggest that NHE-1 inhibitors attenuate cardiomyocyte hypertrophy in response to various stimuli whereas in vivo studies report substantial attenuation of both hypertrophy and heart failure by these agents, especially after myocardial infarction. Accordingly. NHE-1 inhibitors could emerge as important therapeutic tools for the attenuation and treatment of heart failure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 07:19:58