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Titolo:
Postmenopausal oestrogen replacement therapy and atherosclerosis: can current compounds provide cardiovascular protection?
Autore:
Barton, M;
Indirizzi:
Univ Zurich Hosp, Dept Internal Med, CH-8091 Zurich, Switzerland Univ Zurich Hosp Zurich Switzerland CH-8091 CH-8091 Zurich, Switzerland Univ Zurich Hosp, Med Policlin, CH-8091 Zurich, Switzerland Univ Zurich Hosp Zurich Switzerland CH-8091 CH-8091 Zurich, Switzerland Univ Zurich Hosp, Clin Atherosclerosis Res Lab, CH-8091 Zurich, Switzerland Univ Zurich Hosp Zurich Switzerland CH-8091 CH-8091 Zurich, Switzerland
Titolo Testata:
EXPERT OPINION ON INVESTIGATIONAL DRUGS
fascicolo: 5, volume: 10, anno: 2001,
pagine: 789 - 809
SICI:
1354-3784(200105)10:5<789:PORTAA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
ESTROGEN-RECEPTOR-BETA; CORONARY HEART-DISEASE; NITRIC-OXIDE-SYNTHASE; VASCULAR SMOOTH-MUSCLE; CHOLESTEROL-FED RABBITS; ENDOTHELIUM-INDEPENDENT RELAXATION; CONJUGATED EQUINE ESTROGENS; CELLS IN-VITRO; BREAST-CANCER; ARTERY ATHEROSCLEROSIS;
Keywords:
antioxidant; atherosclerosis; cardiovascular; coronary artery disease; endothelium; HRT; inflammation; medroxyprogesterone acetate; myocardial infarction; oestrogen deficiency; 17 beta-oestradiol; oestrogen; oestrogen receptor; plaque stability; progesterone; stroke; SERMs; vasomotion;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
255
Recensione:
Indirizzi per estratti:
Indirizzo: Barton, M Univ Zurich Hosp, Dept Internal Med, Ramistr 100, CH-8091 Zurich, Switzerland Univ Zurich Hosp Ramistr 100 Zurich Switzerland CH-8091 zerland
Citazione:
M. Barton, "Postmenopausal oestrogen replacement therapy and atherosclerosis: can current compounds provide cardiovascular protection?", EXPERT OP I, 10(5), 2001, pp. 789-809

Abstract

The natural oestrogen. 17 beta -oestradiol, has been implicated in protection from atherosclerosis, a chronic systemic vascular disease with an inflammatory component accounting for the majority of morbidity and mortality inWestern countries. Despite the protective effects of 17 beta -oestradiol in premenopausal women and experimental evidence demonstrating inhibitory effects of oestrogen on atherosclerosis progression it is currently unclear whether hormone replacement therapy can affect cardiovascular morbidity and mortality in postmenopausal women. The recent advances in understanding themechanisms of oestrogen action demonstrated roles for different oestrogen receptors and oestrogen metabolites in the pathogenesis of vascular injury and endothelial cell dysfunction. However, their respective role in the process of atherogenesis remains yet to be elucidated. Moreover. the availability of novel drugs with tissue- and/or receptor-specific actions will help to understand the role of oestrogen in cardiovascular diseases. Several ongoing large-scale clinical trials using opposed or unopposed replacement therapy with natural or synthetic oestrogens, or selective oestrogen receptor modulators (SERMs) will resolve the question whether the drugs currently available have therapeutic potential to interfere with the progression of atherosclerosis and its complications.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:43:30