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Titolo:
The role of inducible-nitric oxide in cocaine-induced kindling
Autore:
Park, KK; Reuben, JS; Soliman, KFA;
Indirizzi:
Florida A&M Univ, Coll Pharm & Pharmaceut Sci, Tallahassee, FL 32307 USA Florida A&M Univ Tallahassee FL USA 32307 Sci, Tallahassee, FL 32307 USA
Titolo Testata:
EXPERIMENTAL BIOLOGY AND MEDICINE
fascicolo: 3, volume: 226, anno: 2001,
pagine: 185 - 190
SICI:
1535-3702(200103)226:3<185:TROIOI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYNTHASE INHIBITORS; L-ARGININE; MICE; EXPRESSION; HIPPOCAMPUS; GLUTAMATE; INDUCTION; BRAIN; LIPOPOLYSACCHARIDE; SENSITIZATION;
Keywords:
cocaine; kindling; NMDA receptor; seizures; iNOS; nitric oxide; hippocampus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Soliman, KFA Florida A&M Univ, Coll Pharm & Pharmaceut Sci, Tallahassee, FL 32307 USA Florida A&M Univ Tallahassee FL USA 32307 ssee, FL 32307 USA
Citazione:
K.K. Park et al., "The role of inducible-nitric oxide in cocaine-induced kindling", EXP BIOL ME, 226(3), 2001, pp. 185-190

Abstract

Experimentally naive male Sprague Dawley rats (weighing 85-110 g) were used to examine the role of inducible nitric oxide synthase (iNOS) in cocaine-induced kindling. Repeated administration of cocaine 145 mg/kg, ip) to Sprague Dawley male rats for 7 consecutive days produced a progressive increasein the convulsive responsiveness and death. Pretreatment with iNOS inhibitors, L-N-6-(1-iminoethyl)lysine (NIL; 10 mg/kg, ip) and (-)epigalloocatechin gallate (EGCG; 10 mg/kg, ip) 30 min before cocaine (45 mg/kg, ip) administration for 7 days attenuated the development of cocaine kindling and blocked cocaine-induced death. Results of NMDA receptor binding assay in the hippocampus showed a significant increase in the affinity without changes in the density in animals treated with cocaine, but there were no changes in these parameters in the cortex. Pretreatment with NIL or EGCG prior to cocaine administration abolished the cocaine-induced effect in the NMDA receptor affinity in the hippocampus, These results suggest that iNOS induction followed by an increase of NMDA receptor affinity in the hippocampus after repeated exposure to cocaine may participate in the process of the development of cocaine kindling.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 12:04:12