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Titolo:
Superantigens: The good, the bad, and the ugly
Autore:
Torres, BA; Kominsky, S; Perrin, GQ; Hobeika, AC; Johnson, HM;
Indirizzi:
Univ Florida, Dept Microbiol & Cell Sci, Gainesville, FL 32611 USA Univ Florida Gainesville FL USA 32611 Cell Sci, Gainesville, FL 32611 USA Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 v, Med Ctr, Dept Surg, Durham, NC 27710 USA
Titolo Testata:
EXPERIMENTAL BIOLOGY AND MEDICINE
fascicolo: 3, volume: 226, anno: 2001,
pagine: 164 - 176
SICI:
1535-3702(200103)226:3<164:STGTBA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; STAPHYLOCOCCAL-ENTEROTOXIN-A; TOXIC-SHOCK-SYNDROME; MAMMARY-TUMOR VIRUS; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; PREGNANCY RECOGNITION HORMONE; HUMAN PERIPHERAL LYMPHOCYTES; HUMAN-IMMUNODEFICIENCY-VIRUS; OVINE TROPHOBLAST PROTEIN-1; IFN-GAMMA INDUCTION;
Keywords:
superantigens; autoimmunity; cancer; prophylactic vaccination;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
116
Recensione:
Indirizzi per estratti:
Indirizzo: Johnson, HM Univ Florida, Dept Microbiol & Cell Sci, Box 110700, Gainesville, FL 32611USA Univ Florida Box 110700 Gainesville FL USA 32611 , FL 32611USA
Citazione:
B.A. Torres et al., "Superantigens: The good, the bad, and the ugly", EXP BIOL ME, 226(3), 2001, pp. 164-176

Abstract

Increasing evidence suggests that superantigens play a role in immune-mediated diseases. Superantigens are potent activators of CD4(+) T cells, causing rapid and massive proliferation of cells and cytokine production. This characteristic of superantigens can be exploited in diseases where strong immunologic responses are required, such as in the B16F10 animal model of melanoma. Superantigen administration is able to significantly enhance ineffective anti-tumor immune responses, resulting in potent and long-lived protective anti-tumor immunity. However, superantigens are more well-known for the role they play in diseases. Studies using an animal model for neurologic demyelinating diseases such as multiple sclerosis show that superantigens can induce severe relapses and activate autoreactive T cells not involved inthe initial bout of disease. This may also involve epitope spreading of disease. Superantigens have also been implicated in acute diseases such as food poisoning and TSS, and in chronic diseases such as psoriasis and rheumatoid arthritis. Viral superantigens are also involved in the disease process, including superantigens derived from human immunodeficiency virus and mouse mammary tumor virus. Finally, immunotherapies that ameliorate the role played by superantigens in disease are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 22:36:29