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Titolo:
Blood glutathione and cysteine concentrations in twin children
Autore:
Lang, CA; Matheny, AP; Mastropaolo, W; Liu, MC;
Indirizzi:
Univ Louisville, Sch Med, Dept Biochem & Mol Biol, Louisville, KY 40292 USA Univ Louisville Louisville KY USA 40292 ol Biol, Louisville, KY 40292 USA Univ Louisville, Sch Med, Dept Pediat, Louisville, KY 40292 USA Univ Louisville Louisville KY USA 40292 Pediat, Louisville, KY 40292 USA Univ Louisville, Sch Med, Dept Pathol & Lab Med, Louisville, KY 40292 USA Univ Louisville Louisville KY USA 40292 Lab Med, Louisville, KY 40292 USA
Titolo Testata:
EXPERIMENTAL BIOLOGY AND MEDICINE
fascicolo: 4, volume: 226, anno: 2001,
pagine: 349 - 352
SICI:
1535-3702(200104)226:4<349:BGACCI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIFE-SPAN; MOUSE; DISULFIDES; CYST(E)INE; THIOLS;
Keywords:
blood; glutathione; cysteine; twin children;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Lang, CA Univ Louisville, Sch Med, Dept Biochem & Mol Biol, MDR 412, Louisville, KY40292 USA Univ Louisville MDR 412 Louisville KY USA 40292 ille, KY40292 USA
Citazione:
C.A. Lang et al., "Blood glutathione and cysteine concentrations in twin children", EXP BIOL ME, 226(4), 2001, pp. 349-352

Abstract

Glutathione and cysteine are major antioxidants in blood that are associated with health and longevity. To ensure their measurement, careful attention to avoid auto-oxidation is necessary to stabilize the samples. Since no report of these compounds has been reported in children. our goal was to determine their levels of reduced and oxidized glutathione (GSH and GSSG) and cysteine (Cys and CSSC), To this end, 140 healthy children, ages 2 to 9 years from the Louisville Twin Study were studied. Blood samples were collected and analyzed for GSH, GSSG, Cys, and CSSC by our HPLC dual electrochemical method. The results showed that GSH and total GSH (GSH + GSSG) levels formonozygotic (MZ) twins were significantly higher (P < 0.001) than levels for dizygotic (DZ) twins. However, the opposite occurred for Cys and total Cys (Cys + CSSC) in that the levels were significantly higher for DZ twins than for MZ twins, (P < 0.005-0.013), In spite of this marked difference in zygosity, the within-pair correlations for twin pairs used for estimating heritability suggested that there was a major environmental influence for total GSH and total Cys, Finally. GSH levels were significantly lower for young (2-9 years) children than adults (P < 0.001).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 15:10:04