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Titolo:
Collagen characteristics and organization during the progression of cholesterol-induced atherosclerosis in Japanese quail
Autore:
Velleman, SG; McCormick, RJ; Ely, D; Jarrold, BB; Patterson, RA; Scott, CB; Daneshvar, H; Bacon, WL;
Indirizzi:
Ohio State Univ, Ohio Agr Res & Dev Ctr, Dept Anim Sci, Wooster, OH 44691 USA Ohio State Univ Wooster OH USA 44691 Dept Anim Sci, Wooster, OH 44691 USA Univ Wyoming, Dept Anim Sci, Laramie, WY 82071 USA Univ Wyoming Laramie WY USA 82071 g, Dept Anim Sci, Laramie, WY 82071 USA Univ Akron, Dept Biol, Akron, OH 44325 USA Univ Akron Akron OH USA 44325Univ Akron, Dept Biol, Akron, OH 44325 USA
Titolo Testata:
EXPERIMENTAL BIOLOGY AND MEDICINE
fascicolo: 4, volume: 226, anno: 2001,
pagine: 328 - 333
SICI:
1535-3702(200104)226:4<328:CCAODT>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
CROSS-LINKING; BLOOD; HYPERTROPHY; PHENOTYPES; ELASTIN; AORTA; HEART; RATS;
Keywords:
atherosclerosis; cholesterol; collagen; extracellular matrix; hydroxypyridinoline;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Velleman, SG Ohio State Univ, Ohio Agr Res & Dev Ctr, Dept Anim Sci, 1680 Madison Ave, Wooster, OH 44691 USA Ohio State Univ 1680 Madison Ave WoosterOH USA 44691 691 USA
Citazione:
S.G. Velleman et al., "Collagen characteristics and organization during the progression of cholesterol-induced atherosclerosis in Japanese quail", EXP BIOL ME, 226(4), 2001, pp. 328-333

Abstract

This study reports the concentration of collagen and its hydroxypyridinoline crosslinks, collagen fibril organization in the dorsal aortas, and systolic blood pressure during the progression of atherosclerosis in Japanese quail selected for cholesterol-induced atherosclerosis, The quail were placedon either a control or 0.5% cholesterol-added diet at approximately 16 weeks of age, The concentration of total collagen did not change in the control arteries during the course of the study, whereas at 5 and 10 weeks of cholesterol feeding, collagen levels decreased in the cholesterol-fed birds. Hydroxypyridinoline concentration increased during the duration of the studyin the ho[cholesterol-fed birds and by 15 and 20 weeks of cholesterol feeding, levels were significantly increased over those observed in the controlarteries. Transmission electron microscopy showed changes in the organization of collagen fibrils, Increased systolic blood pressure was noted beginning at 10 weeks of cholesterol feeding, which is suggestive of other systemic changes induced by hypercholesterolemia. These results demonstrated remodeling of the collagen component of the dorsal aorta extracellular matrix during the progression of atherosclerosis and are suggestive of other systemic cardiovascular system changes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 07:57:59