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Titolo:
Effects of the xenoestrogen bisphenol A on expression of vascular endothelial growth factor (VEGF) in the rat
Autore:
Long, X; Burke, KA; Bigsby, RM; Nephew, KP;
Indirizzi:
Indiana Univ, Sch Med, Bloomington, IN 47405 USA Indiana Univ BloomingtonIN USA 47405 Sch Med, Bloomington, IN 47405 USA Indiana Univ, Sch Med, Dept Obstet & Gynecol, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 ynecol, Indianapolis, IN 46202 USA
Titolo Testata:
EXPERIMENTAL BIOLOGY AND MEDICINE
fascicolo: 5, volume: 226, anno: 2001,
pagine: 477 - 483
SICI:
1535-3702(200105)226:5<477:EOTXBA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
FEMALE REPRODUCTIVE-TRACT; QUANTITATIVE TRAIT LOCI; GENE-EXPRESSION; ENVIRONMENTAL ESTROGEN; HUMAN ENDOMETRIUM; SPLICE VARIANTS; MENSTRUAL-CYCLE; FACTOR FAMILY; TUMOR-GROWTH; UTERINE;
Keywords:
vascular endothelial growth factor; Bisphenol A; xenoestrogen; uterus; vagina; pituitary; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Nephew, KP Indiana Univ, Sch Med, Jordan Hall,1001 3rd St, Bloomington, IN47405 USA Indiana Univ Jordan Hall,1001 3rd St Bloomington IN USA 47405 A
Citazione:
X. Long et al., "Effects of the xenoestrogen bisphenol A on expression of vascular endothelial growth factor (VEGF) in the rat", EXP BIOL ME, 226(5), 2001, pp. 477-483

Abstract

Bisphenol-A (BPA) is used to produce polymers for production of polycarbonate and epoxy resins that are used in food containers and dental appliances. BPA binds to estrogen receptors and induces estrogenic activity in a number of biological systems. We recently reported that although Fisher 344 (F344) and Sprague-Dawley (S-D) rat strains exhibit different sensitivities toBPA at the level of vaginal epithelial cell proliferation, there was no difference in immediate early proto-oncogene expression between the two animal strains. In the present study we investigated the effects of BPA on expression of another estrogen-target gene, vascular endothelial growth factor (VEGF), in the uterus, vagina, and pituitary of F344 and S-D rats. Adult rats were ovariectomized and treated with BPA by intraperitoneal injection at concentrations of 0.02 to 150 mg/kg body wt. Expression of VEGF was monitored by RNase protection assay at 2 hr after treatment. There was a significant effect of dose of BPA on the type of VEGF isoform expressed in the uterus, vagina, and pituitary, BPA induced greater (P < 0.01) levels of VEGF(164) and VEGF(120+188) than VEGF(110) levels. The lowest BPA dose that had a significant (P < 0.05) effect on VEGF expression compared with vehicle treatment was 37.5 mg/kg body wt.; dose-response curves did not differ between strains. This is the first report that the primary response of the uterus, vagina, and pituitary to BPA includes rapid induction of VEGF expression. Due to the capacity of VEGF to engage pleiotropic signaling pathways in othercellular systems, we suggest that modulation of VEFG may play a role in establishing the response of estrogen-target organs to estrogenic xenobiotics.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 10:06:38