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Titolo:
Genetics of arterial prothrombotic risk states
Autore:
Williams, MS; Bray, PF;
Indirizzi:
Baylor Coll Med, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 ylor Coll Med, Houston, TX 77030 USA Johns Hopkins Univ, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 s Univ, Baltimore, MD 21205 USA
Titolo Testata:
EXPERIMENTAL BIOLOGY AND MEDICINE
fascicolo: 5, volume: 226, anno: 2001,
pagine: 409 - 419
SICI:
1535-3702(200105)226:5<409:GOAPRS>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLATELET GLYCOPROTEIN IIIA; PLASMINOGEN-ACTIVATOR INHIBITOR-1; CORONARY HEART-DISEASE; COAGULATION-FACTOR-VII; ACUTE MYOCARDIAL-INFARCTION; C-REACTIVE PROTEIN; FACTOR-V-LEIDEN; METHYLENETETRAHYDROFOLATE REDUCTASE GENE; PLASMA-FIBRINOGEN CONCENTRATIONS; AMINO-ACID POLYMORPHISM;
Keywords:
genetics; thrombosis; coronary artery; platelets; risk factors;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
152
Recensione:
Indirizzi per estratti:
Indirizzo: Bray, PF Baylor Coll Med, 1 Baylor Pl,BCN 286,N1319, Houston, TX 77030 USABaylor Coll Med 1 Baylor Pl,BCN 286,N1319 Houston TX USA 77030 SA
Citazione:
M.S. Williams e P.F. Bray, "Genetics of arterial prothrombotic risk states", EXP BIOL ME, 226(5), 2001, pp. 409-419

Abstract

Coronary artery disease is a leading cause of death worldwide and the largest killer of men and women in the United States. The pathophysiology of myocardial infarction is multifactorial, and numerous physiologic systems converge to dictate the formation of the two fundamental lesions, thrombosis and atherosclerosis. In this review we address genetic aspects of arterial thrombosis and the key thrombotic factors that have been associated with theincreased risk for its development. Specifically, we consider components of coagulation, fibrinolysis, and platelet adhesive receptors, and we reviewthe genetic epidemiology and in vitro laboratory data regarding their riskfor the acute coronary syndromes. In combination with traditional risk factor assessment, in the near future these inherited markers can be used to manage patients with vascular disease through a better utilization of invasive or expensive diagnostic testing, as well as pharmacologic intervention.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 17:50:04