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Titolo:
New concepts in characterization of ischemically injured myocardium by MRI
Autore:
Saeed, M;
Indirizzi:
Univ Calif San Francisco, Sch Med, Dept Radiol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
EXPERIMENTAL BIOLOGY AND MEDICINE
fascicolo: 5, volume: 226, anno: 2001,
pagine: 367 - 376
SICI:
1535-3702(200105)226:5<367:NCICOI>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; REPERFUSED INFARCTED MYOCARDIUM; POSITRON EMISSION TOMOGRAPHY; DELAYED CONTRAST-ENHANCEMENT; NO-REFLOW PHENOMENON; PERFUSED RAT-HEART; GD-DTPA; MICROVASCULAR OBSTRUCTION; ECHO-PLANAR; DISTRIBUTION VOLUME;
Keywords:
myocardial viability; myocardial injury; myocardial infarction; coronary artery disease; magnetic resonance imaging;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
94
Recensione:
Indirizzi per estratti:
Indirizzo: Saeed, M Univ Calif San Francisco, Sch Med, Dept Radiol, 505 Parnassus Ave,L308, San Francisco, CA 94143 USA Univ Calif San Francisco 505 Parnassus Ave,L308 San Francisco CA USA 94143
Citazione:
M. Saeed, "New concepts in characterization of ischemically injured myocardium by MRI", EXP BIOL ME, 226(5), 2001, pp. 367-376

Abstract

New concepts regarding the assessment of ischemic myocardial injuries havebeen addressed in this Minireview using magnetic resonance imaging (MRI). MRI, with its different techniques, brings not only anatomic, but also physiologic, information on ischemic heart disease. It has the ability to measure identical parameters in preclinical and clinical studies. MRI techniquesprovide the ideal package for repeated and noninvasive assessment of myocardial anatomy, viability, perfusion, and function. MR contrast agents can be applied in a variety of ways to improve MRI sensitivity for detecting andassessing ischemically injured myocardium. With MR contrast agents protocol, it becomes possible to identify ischemic, acutely infarcted, and peri-infarcted myocardium in occlusive and reperfused infarctions. Necrosis specific and nonspecific extracellular contrast-enhanced MRI has been used to assess myocardial viability. Contrast-enhanced perfusion MRI can explore the disturbances in large (angiography) and small coronary arteries (myocardial perfusion) as the underlying cause of myocardial dysfunction, Perfusion MRIhas been used to measure myocardial perfusion (ml/min/g) and to demonstrate the difference in transmural myocardial blood flow. Information on no-reflow phenomenon is derived from dynamic changes in regional signal intensityafter bolus injection of MR contrast agents. Another development is the near future availability of blood pool MR contrast agents. These agents are able to assess microvascular permeability and integrity and are advantageousin MR angiography (MRA) due to their persistence in the blood. Noncontrast-enhanced MRI such as cine MRI at rest/stress, sodium MRI, and MR spectroscopy also have the potential to noninvasively assess myocardial viability inpatients. Futuristic applications for MRI in the heart will focus on identifying coronary artery disease at an early stage and the beneficial effectsof new therapeutic agents such as intra-arterial gene therapy. MR techniques will have great future in the drug discovery process and in testing the effects of drugs on myocardial biochemistry, physiology, and morphology. Molecular imaging is going to bloom in this decade.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:22:29