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Titolo:
Topographical assessment and pharmacological characterization of orofacialmovements in mice: dopamine D-1-like vs. D-2-like receptor regulation
Autore:
Tomiyama, K; McNamara, FN; Clifford, JJ; Kinsella, A; Koshikawa, N; Waddington, JL;
Indirizzi:
Royal Coll Surg Ireland, Dept Clin Pharmacol, Dublin 2, Ireland Royal CollSurg Ireland Dublin Ireland 2 in Pharmacol, Dublin 2, Ireland Nihon Univ, Sch Dent, Dept Pharmacol, Tokyo 1018310, Japan Nihon Univ Tokyo Japan 1018310 ent, Dept Pharmacol, Tokyo 1018310, Japan Dublin Inst Technol, Dept Math, Dublin 8, Ireland Dublin Inst Technol Dublin Ireland 8 chnol, Dept Math, Dublin 8, Ireland
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 1-2, volume: 418, anno: 2001,
pagine: 47 - 54
SICI:
0014-2999(20010420)418:1-2<47:TAAPCO>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
TARGETED GENE DELETION; JAW MOVEMENTS; ADENYLYL-CYCLASE; RAT-BRAIN; STIMULATION; AGONISTS; D-1; SK-AND-F-83959; ANTAGONISTS; DYSKINESIA;
Keywords:
dopamine D-1-like and D-2-like receptor; orofacial movement topography; dopamine D-1-like receptor; non-cyclase-coupled; dopamine D-1-like; D-2-like receptor interaction; A 68930; SK&F 83959; (mouse);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Waddington, JL Royal Coll Surg Ireland, Dept Clin Pharmacol, 123 St Stephens Green, Dublin 2, Ireland Royal Coll Surg Ireland 123 St Stephens Green Dublin Ireland 2
Citazione:
K. Tomiyama et al., "Topographical assessment and pharmacological characterization of orofacialmovements in mice: dopamine D-1-like vs. D-2-like receptor regulation", EUR J PHARM, 418(1-2), 2001, pp. 47-54

Abstract

A novel procedure for the assessment of orofacial movement topographies inmice was used to study, for the first time, the individual and interactiveinvolvement of dopamine D-1-like vs. D-2-like receptors in their regulation. The dopamine D-1-like receptor agonists a 68930 ([1R,3S]-1-aminomethyl-5,6-dihydroxy-3-phenyl-isochroman) and SK&F 83959 (3-methyl-6-chloro-7,8-dihydroxy-1-[3-methylphenyl]-2,3,il,5-tetrahydro-1H-3-benzazepine) each induced vertical jaw movements with tongue protrusions and incisor chattering. The dopamine D-1-like receptor antagonists SCH 23390 ([R]-3-methyl-7-chloro-8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine) and BW 737C ([S]-6-chloro-1-[2,5-dimethoxy-4-propylbenzyl]-7-hydroxy-2-methyl-1,2,3,4-tetrahydroisoquinoline) antagonised these responses, while the dopamine D-2-like receptor antagonist YM 09151-2 (cis-N-[1-benzyl-2-methyl-pyrrolidin-3-yl]-5-chloro-2-methoxy-4-methylaminobenzamide) attenuated those to SK&F 83959 and released horizontal jaw movements. These findings suggest some role for a dopamine D-1-like receptor that is coupled to a transduction system other than/additional to adenylyl cyclase? and for dopamine D-1-like:D-2-like receptor interactions, in the regulation of individual orofacial movement topographies in the mouse. This methodology will allow the use of knockout mice toclarify the roles of individual dopamine receptor subtypes in their regulation. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 22:18:36